Dr Sophocles Chrissobolis

Current Position

NHMRC Overseas Postdoctoral Fellow

Address

Department of Pharmacology
Monash University
Clayton, Victoria, 3800  Australia

Email: sophocles.chrissobolis@monash.edu
Phone:  +61 3 9905 0914
Facsimile:  +61 3 9902 9500

Dr Sophocles Chrissobolis completed his PhD at the University of Melbourne in the Department of Pharmacology where he investigated how potassium channels and rho-kinase are involved in cerebral vascular function under normal conditions and during chronic hypertension.  In 2004, he was awarded an NHMRC CJ Martin Overseas Training Fellowship to work at the University of Iowa in the United States under the mentorship of Professor Frank Faraci.  In 2005 he was awarded the Chancellor’s prize at The University of Melbourne for excellence in his PhD thesis.  While in Iowa, Dr Chrissobolis studied the involvement of antioxidant defense mechanisms in protecting against vascular dysfunction caused by angiotensin II.  The American Heart Association awarded Dr Chrissobolis a Postdoctoral Fellowship in 2007 to continue his work at Iowa. Currently under the mentorship of A/Prof Chris Sobey, Dr Chrissobolis joined the Vascular Biology and Immunopharmacology group in 2009.  Of Dr Chrissobolis’ 14 publications to date, 9 are in journals of the American Heart Association.  His current research is focused on mechanisms by which aldosterone and angiotensin II are involved in cerebrovascular disease.

Journal Publications

Chrissobolis, S. and Faraci, F.M.  (2010).  Sex Differences in Protection Against Angiotensin II-Induced Endothelial Dysfunction by Manganese Superoxide Dismutase in the Cerebral Circulation.  Hypertension.  55: 905-910.

Chrissobolis, S. and Faraci, F.M. (2008).  The Role of Oxidative Stress and NADPH oxidase in Cerebrovascular Disease.  Trends In Molecular Medicine 14:495-502.

Chrissobolis, S., Didion, S.P., Kinzenbaw, D.A., Schrader, L.I., Dayal, S., Lentz, S.R. and Faraci, F.M.  (2008).  Glutathione Peroxidase-1 Plays a Major Role in Protecting Against Angiotensin II-Induced Vascular Dysfunction.  Hypertension.  51: 872-877 (featured in an editorial, Hypertension 51:825-826, 2008).

Jackman, K.A., Woodman, O.L., Chrissobolis, S. and Sobey, C.G.  (2007).  Vasorelaxant and antioxidant activity of the isoflavone metabolite equol in carotid and cerebral arteries.  Brain Research. 1141:99-107.

Chrissobolis, S. and Sobey, C.G. (2006).  Recent Evidence for an Involvement of Rho-Kinase in Cerebral Vascular Disease.  Stroke 37:2174-2180.

Chrissobolis, S., Budzyn, K., Marley, P.D. and Sobey, C.G.  (2004).  Evidence that Estrogen Suppresses Rho-Kinase Function in the Cerebral Circulation In
Vivo.  Stroke 35:2200-2205.

Chrissobolis, S. and Sobey, C.G.  (2004).  Influence of Gender on K+-Induced Cerebral Vasodilatation.  Stroke 35:747-752.

Paravicini, T.M., Chrissobolis, S., Drummond, G.R. and Sobey, C.G. (2004).  NADPH-Oxidase Activity Causes H2O2-Mediated Cerebral Vasodilatation In Vivo and is Enhanced in Hypertension.  Stroke 35:584-589.

Chrissobolis, S. and Sobey, C.G. (2003).  Inwardly Rectifying Potassium Channels In The Regulation of Vascular Tone.  Current Drug Targets 4:281-289.

Chrissobolis, S. and Sobey, C.G. (2002).  Inhibitory effects of protein kinase C on inwardly rectifying K+- and ATP-sensitive K+ channel-mediated responses of the basilar artery.  Stroke 33:1692-1697.

Chrissobolis, S., Ziogas, J., Anderson, C.R., Chu, Y., Faraci, F.M. and Sobey, C.G. (2002).  Neuronal NO mediates cerebral vasodilator responses to K+ in hypertensive rats.  Hypertension 39:880-885.

Faraci, F.M., Sobey, C.G., Chrissobolis, S., Lund, D.D., Heistad, D.D. and Weintraub, N. (2001).  Arachidonate dilates basilar artery by a lipoxygenase-dependent mechanism and activation of K+ channels.  American Journal of Physiology Reg Int Comp Physiol 281:R246-R253.

Chrissobolis, S. and Sobey, C.G. (2001).  Evidence that rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension: comparison with protein kinase C.  Circulation Research 88:774-779.

Chrissobolis, S., Ziogas, J., Chu, Y., Faraci, F.M. and Sobey, C.G. (2000).  Role of inwardly rectifying K+ channels in K+-induced cerebral vasodilatation in vivo.  American Journal of Physiology Heart Circ Physiol 279:H2704-H2712.