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Professor Roger Summers

Professor Roger Summers

CURRENT POSITIONS

Professor of Molecular Pharmacology
Lab Head, Drug Discovery Biology Laboratory

ADDRESS

Drug Discovery Biology Laboratory
Department of Pharmacology
Monash University
Clayton, Victoria, 3800
Australia
Ph: +613 9905 1440
Fax: +613 9905 8192
Email: roger.summers@med.monash.edu.au


Overview


EDUCATION

 1965  Pharmacy College Brunswick Square, UK  University of London  B.Pharm (Hons1)
 1968  National Institute for Medical Research, Mill Hill, UK  University of London  Ph.D
 2005  British Pharmacological Society, UK  British Pharmacological Society  F.B.Pharmacol. Soc
 2006  Stockholm, Sweden  University of Stockholm  Ph.D (honoris causa)


RESEARCH FOCUS

The principal direction of our laboratory is towards understanding novel modes of regulation of GPCRs in an effort to identify novel targets or approaches for drug discovery. Our work encompasses investigation across virtually all levels of GPCR structure/function, including analysis of the functional significance of single nucleotide polymorphisms, RNA-editing and alternate mRNA splicing; signaling via G proteins and downstream messenger systems; interaction of receptors with regulatory accessory proteins; novel allosteric GPCR binding sites, ligand-directed signalling and mathematical and molecular modeling of GPCR-ligand interactions

Drug Discovery Biology


AWARDS

1965-68 Medical Research Council Scholarship forTraining in Research Methods at the National Institute for Medical Research, Mill Hill, UK
1977-78 Visiting Research Fellowship, Clinical Pharmacology Unit, Austin Hospital, Melbourne
1979-80 NH & MRC Research Fellowship
1980-84 NH & MRC Senior Research Fellowship
1982 Visiting Scientist in Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA
1986 David Syme Research Prize
1988 Visiting Scientist Howard Florey Institute, Melbourne
1991 ASCEPT/British Pharmacol Soc Visiting Lecturer
1992 NHF, Kathleen & Lovat Fraser Award 
1996 Honorary Research Fellowship, University of Leicester, U.K.
2003 Visiting Professor Toho University, Chiba, Japan
2003 Tage Erlander Visiting Professor, Swedish Research Council
2003 Michael Rand Medal, ASCEPT 
2004 Honorary Senior Principal Research Fellowship, Howard Florey Institute
2005  Fellow of the British Pharmacological Society
2006 Honorary Doctorate honoris causa – Stockholm University, Sweden


CURRENTLY HELD GRANTS

2009 - 2013: P.M. Sexton, A. Christopoulos, and R.J. Summers, "Understanding G protein coupled receptors: Accelerating discovery from concept to clinic", National Health and Medical Research Council of Australia Program Grant ID No 519461.
2008 - 2010: Summers & B.A. Evans,  "Novel actions of beta-adrenoceptor antagonists: implications for the treatment of cardiac failure" National Health and Medical Research Council of Australia Project Grant ID No 491190
2008 - 2010: D.S. Hutchinson & R.J. Summers, "Understanding the mechanisms used by G-protein coupled receptors to regulate insulin-independent glucose transport" National Health and Medical Research Council of Australia Project Grant ID No 491169
2009: ARC Linkage International Fellowship. Dr Masaaki Sato
2007 - 2009: R.J. Summers, R.A.D. Bathgate "Understanding cell signalling mechanisms activated by relaxin family peptides: targets with therapeutic potential" National Health and Medical Research Council of Australia Project Grant ID No 436713
2007-2009: R.A.D. Bathgate, R.J. Summers, J.D. Wade, G.W. Tregear, P.R. Gooley "Determinants of binding and activity of G-protein coupled receptors RXFP1 and RXFP2 the receptors for relaxin and INSL3" National Health and Medical Research Council of Australia Project Grant ID No 454375


CURRENT COLLABORATORS

Prof. Patrick Sexton Dept. of Pharmacology, Monash University, Melbourne, Australia
Prof Arthur Christopoulos Dept. of Pharmacology, Monash University, Melbourne, Australia
Dr Geoff Tregear Howard Florey Institute
Dr Ross Bathgate Howard Florey Institute
Dr Christian Samuel Howard Florey Institute
Prof Barbara Cannon Wenner-Gren Institute Stockholm University
A/Prof Tore Bengtsson Wenner-Gren Institute Stockholm University
Prof Ulo Langel Wenner-Gren Institute Stockholm University
Dr Marie Gibbs Department of Anatomy, Monash University


CURRENT PROFESSIONAL AFFILIATIONS

1972 – present: British Pharmacological Society
1975 - present: Physiological Society
1979 - present: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT).
1980 – present: Australian Neuroscience Society
1997 – present: Member Australian Society for the Study of Obesity
2005 - present: Fellow of the British Pharmacological Society
2006 - present: Member American Society for Pharmacology and Experimental Therapeutics


PROFESSIONAL ACTIVITIES

2002 - present  Editor Trends in Pharmacological Sciences
2004-present  Editor x-Pharmacology
2008-present  Member Advisory Board Faculty of 1000 Biology


CURRENT TEACHING RESPONSIBILITIES

2006 - present: Unit Co-ordinator, 3rd Year Science (Monash University) PHA3042 “Modern drug development”.
2006 - present: Present: 3rd Year Science (Monash University) Pharmacology PHA3042 Drug Discovery and Development - 2 Lectures “Introduction to Drug Discovery”; "Pharmacogenomics".
2006 - present: 3rd Year Science (Monash University) Pharmacology PHA3042 Drug Discovery and Development - 3 practicals (twice weekly) "Receptor binding assay"; "Functional high-throughput screening"; "In vitro assay".
2006 - present: 3rd Year Science (Monash University) Pharmacology PHA3042 Drug Discovery and Development - Assignment presentations assessment (2 days).
1997 - present: 3rd Year Science (Monash University) Pharmacology PHA3011 Principles of Pharmacology - 4 Lectures “Molecular families of Receptors”; "Second Messengers"; "Adrenergic transmission I and II".
1997 - present: 4th Year Science (Monash University) Pharmacology Honours PHA4000 - 2 Lectures “Receptor regulation”; "Second Messengers"
1997 - 2008: 4th Year Science (Monash University) Pharmacology Honours PHA4000 - 1 Advanced practical “Receptor Binding techniques”.
2001 - 2008: 3rd year Biomedical Science (Monash University) BMS3021: 3 lectures "Pharmacogenetics"; "Drug Discovery"; "Drug design and development".
1997 - 2008: Radiography RAD2031: 3 lectures "Introduction to autonomic pharmacology"; "Neuromuscular blocking drugs"; "Contrast media for MRI and Ultrasound".


POSTGRADUATE SUPERVISION (since 2000)

 Name Degree  Date Current Position
 Y. Y. Tan PhD  2000 Lecturer in Pharmacology, University of Tasmania
D. S. Hutchinson PhD  2002 RD Wright Fellow, Monash University
C. Bond  PhD  2004 NHF Research Fellow, Monash University
J. Nevzorova PhD  2004 Post-Doctoral Research Fellow Wenner-Gren
B. Popp PhD In progress
N. Phiri PhD  2005 Maternity Leave
M. Sato PhD  2008 ARC Linkage International Fellow
M. Halls PhD  2007 CJ Martin Fellow Cambridge University 
E. van der Westhuizen PhD  2008 Postdoctoral Fellow University of Montreal


PRIZES, AWARDS AND INVITATIONS TO GROUP MEMBERS SINCE 2002

Dana S Hutchison
2003 NHMRC C.J. Martin Fellowship - University of Stockholm
2006 ASCEPT Young Investigator Award
2006 Finalist Presidents Poster Prize, 10th International Conference on Obesity
2007 Invited Speaker Molecular Pharmacology of G Protein-Coupled Receptors Conference
2007 Invited Speaker IBRO satellite on Brain mechanisms, cognition and behaviour in birds
2007 ASCEPT sponsorship to attend the ASMR Professional Development Program
2008 NHMRC RD Wright Fellowship 
Michelle L. Halls
2002 Bachelor of Biomedical Science 3rd Year Prize
2002 Sir John Monash Dean's Scholars Award
2003 Geoff Bentley Prize for Pharmacology (top 3rd-year pharmacology student)
2003 Alan Boura Prize for Pharmacology (top pharmacology Honours student)
2004 Australian Post-graduate Award; Post-graduate Excellence Award (Faculty of Medicine, Nursing and Health Sciences top-up award)
2004 Young Investigator Award 4th International Conference on Relaxin and Related Peptides, Wyoming USA.
2005 Monash University Post-graduate Award to present at the British Pharmacological Society (BPS) Focused Meeting on Cell Signalling, Leicester UK.
2005 ASCEPT Oral Prize in (Australasian Society for Clinical and Experimental Pharmacology and Toxicology; for best student presentation at the annual meeting
2006 IUPHAR travel grant to attend the 15th IUPHAR World Congress of Pharmacology,  Beijing, China.
2006 Runner-up ASCEPT Oral Prize (ASCEPT)
2007 British Pharmacological Society Oral Prize (for best student/post-doctoral presentation) at the 2nd Focused Meeting on Cell Signalling in Leicester, UK.
2007 Molecular Pharmacology of GPCRs Symposium. Monash Drug  Discovery Biology Initiative
Student Poster Prize
2008 NHMRC CJ Martin Fellowship - University of Cambridge
Emma van der Westhuizen
2004 NHMRC Dora Lush Scholarship
2004 Young Investigator Award 4th International Conference on Relaxin and Related Peptides, Wyoming USA.
2005 Monash University Post-graduate Award to present at the British Pharmacological Society (BPS) Focused Meeting on Cell Signalling, Leicester UK.
2005 Runner-up ASCEPT Oral Prize in (Australasian Society for Clinical and Experimental
Pharmacology and Toxicology)
2006 IUPHAR travel grant to attend the 15th IUPHAR World Congress of Pharmacology,  Beijing, China.
2006 ASCEPT-AHMRC meeting – finalist in oral prize section.
2007 Molecular Pharmacology of G Protein-Coupled Receptors Symposium. ASCEPT Student Prize for the best oral presentation.
2008 Fellowship of the Heart and Stroke Foundation of Canada
2008 Fellowship of the Health Research Foundation of Quebec
Stephanie Catus
2007 ASCEPT Whelan prize for the best undergraduate poster at the annual scientific meeting


NATIONAL AND INTERNATIONAL PRESENTATIONS SINCE 2005

 2002 Pharmacology of Adrenoceptors San Francisco USA Pleiotropic coupling of β3-adrenoceptor splice variants
 2002  G-protein coupled receptor symposium Melbourne  β3-Adrenoceptors
 2003  Karolinska  Institute, Stockholm Seminar Coupling of adrenoceptors to multiple signal transduction pathways
 2003  Biovitrum, Stockholm Seminar Selective stimulation of signalling pathways activated by adrenoceptors
 2003 University of Stockholm Frontiers in Bioscience Tage Erlander Lecture  The Janus faces of adrenoceptors – recent advances in the understanding of G-protein coupled receptor signalling
 2003 University of Buckingham, UK Seminar Mechanisms of GPCR mediated glucose uptake in skeletal muscle
 2003 Australiasian Society of Clinical and Experimental Pharmacologists and Toxicologists Michael Rand Medal lecture  The Janus faces of adrenoceptors
 2003 Wenner Gren Institut, Stockholm Molecular and Cellular Aspects of Physiology The use of recombinant adrenoceptor systems to study signal transduction mechanisms
 2003 Toho University, Japan The pharmacology of β3-adrenoceptors
 2004 4th International Relaxin Conference Wyoming USA Pharmacology of LGR7 receptors 
 2004 Peptide receptors-Montreal Role of relaxin in the cardiovascular system – unable to accept
 2004 CPT World Congress Brisbane Australia  Novel Pharmacologies of the β1-  adrenoceptor
 2005 Invited Speaker - British Pharmacological Society Symposium Cambridge UK  Receptors for relaxin family peptides
 2005 University of Melbourne Dept of Physiology  A tail of two receptors: the role of the C-terminus in GPCR signalling
 2005 University of Melbourne Dept of Pharmacology  Receptors for relaxin family peptides
 2005 BAS Medical, San Mateo Signalling pathways utilised by receptors for relaxin family peptides
 2006 Invited Speaker Pharmacology of adrenoceptors – official IUPHAR symposium Beijing China The role of the C-terminal tail in adrenoceptor signalling
 2006 University of Stockholm Public lecture on award of doctorate honoris causa Using reverse pharmacology to de-orphanise receptors: examples from the relaxin family peptides.
 2006 Invited speaker – International Neurological Disease Symposium Shanghai Relaxin signalling in the CNS
 2007 Invited Speaker GPCR Symposium Nottingham April 2007  Pleiotropic signalling of GPCRs – studies with β3-adrenoceptors
 2007 Selected Oral Communication – Life Sciences 2007 Molecular Scaffolds – dynamics and specificity for signalling complex formation – Glasgow UK Functional domains of the mouse β3; adrenoceptor associated with differential G-protein coupling
 2008 Invited Speaker – 5th International Conference on Relaxin and related peptides – Hawaii USA Signalling paradigms demonstrated by receptors for relaxin family peptides
 2008 Wenner Gren Institute, Stockholm Pleiotropic signalling of GPCRs - studies with β3-adrenoceptors
 2008 AHMRC Meeting Brisbane Ligand-directed signalling at GPCRs (plenary)
 2008 GPCR Symposium Sydney Ligand-directed signalling at β3- adrenoceptors


PUBLICATIONS SINCE 2002

  1. Kompa AR, Samuel CS and Summers RJ (2002) Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): effect of pertussis toxin. British Journal of Pharmacology 137: 710-718. (IF = 3.5; Citations = 20) Senior author, original concept, ARK postdoc supervision, data analysis, manuscript preparation
  2. Gibbs, M.E. and Summers, R.J. (2002) Role of adrenoceptors in memory consolidation in the chick. Progress in Neurobiology 67: 345-391. (IF = 11.6, Citations = 27) Senior author, manuscript preparation
  3. Bathgate, R.A.D., Samuel, C.S., Burazin, T.C.D., Layfield, S., Claasz, A.A., Reytomas, I.G.T., Dawson, N.F., Zhao, C., Bond, C., Summers, R.J., Parry, L.J., Wade, J.D. & Tregear, G.W. (2002) Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene: Novel members of the relaxin peptide family. Journal of Biological Chemistry 277:1148-1157. (IF = 6.3, Citations = 96)
  4. Nevzorova J, Bengtsson T, Evans BA and Summers RJ (2002) β2Adrenoceptors mediate increases in glucose transport in rat skeletal muscle cell line L6. British Journal of Pharmacology 137: 9-18. (IF = 3.5, Citations = 11) Senior author, original concept, JN PhD student supervision, data analysis, manuscript preparation
  5. Hutchinson, D.S., Bengtsson, T., Evans, B.A. and Summers, R.J. (2002) Mouse β3a- and β3b-adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilise distinct signalling pathways. British Journal of Pharmacology 135: 1903-1916. (IF = 3.5, Citations = 20) Senior author, original concept, DSH PhD student, TB Postdoctoral Visiting Fellow, data analysis, manuscript preparation
  6. Gibbs ME and Summers RJ (2002) Effects of glucose and 2-deoxyglucose on memory formation in the chick: interaction with β3;adrenoceptor agonists. Neuroscience 114: 69-79. (IF = 3.5, Citations = 9) Senior author, manuscript preparation
  7. Claasz AA, Bond, C, Bathgate RAD, Otvos Jr. L, Dawson NF, Summers RJ, Tregear GW, and Wade JD (2002) Relaxin-like activity of ovine insulin 3 (INSL3) analogues. European Journal of Biochemistry 269: 6287-6293. (IF = 3.2, Citations = 6)
  8. Tan Y-Y, Dawson NF, Kompa AR, Bond CP, Claasz AA, Wade JD, Tregear GW and Summers RJ (2002) Structural requirements for the interaction of sheep insulin-like factor 3 with relaxin receptors in rat atria. European Journal of Pharmacology 457: 153-160. (IF = 2.4, Citations = 6)
  9.  Samuel, C.S., Zhao, C., Bathgate, R.A.D., Bond, C.P., Burton, M.D., Parry, L.P., Summers, R.J., Tang, M.L.K., Amento, E.P. & Tregear, G.W. (2003) Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis. FASEB Journal 17: 121-123. (IF = 7.0, Citations = 42)
  10. Samuel CS, Parry LJ and Summers RJ (2003) Physiological or pathological – a role for relaxin in the cardiovascular system. Current Opinion in Pharmacology 3: 152-158. (IF = 5.6, Citations = 18) Senior author, original concept, manuscript preparation
  11. Samuel CS, Zhao C, Bond CP, Hewitson TD, Amento EP and Summers RJ (2004) Relaxin-1 deficient mice develop an age-related progression of renal fibrosis. Kidney International 65: 2054-2064. (IF = 5.0; Citations = 28) Senior author, CPB PhD student supervision, manuscript preparation 
  12. Bond CP, Parry LJ, Samuel CS, Gehring HM, Lederman FL, Rogers PAW and Summers RJ (2004) Increased expression of the RLX receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle. Journal of Clinical Endocrinology and Metabolism 89: 3477-3485. (IF = 5.7, Citations = 10) Senior author, original concept, CPB PhD student supervision, manuscript preparation
  13. Hutchinson DS, Sato M, Evans BA, Christopoulos A and Summers RJ (2005) Evidence for pleiotropic signalling at the mouse β3-adrenoceptor revealed by SR59230A. Journal of Pharmacology and Experimental Therapeutics 312: 1064-1074. (IF = 4.1, Citations = 6) Senior author, original concept, DSH postdoc supervision, MS PhD student supervision, data analysis, manuscript preparation
  14. Sato M, Hutchinson DS, Bengtsson T, Floren A, Langel Ü, Horinouchi T, Evans BA and Summers RJ (2005) Functional domains of the mouse β3 -adrenoceptor associated with differential G protein coupling.  Journal of Pharmacology and Experimental Therapeutics 315: 1354-1361. (IF = 4.1, Citations = 4) Senior author, original concept, DSH postdoc supervision, MS PhD student supervision, data analysis, manuscript preparation
  15. Gibbs ME and Summers RJ (2005) Contrasting roles for β1-, β2- and β3-adrenoceptors in memory formation in the chick. Neuroscience 131: 31-42. (IF = 3.5, Citations = 4) Halls ML, Bathgate RAD, Roche PJ and Summers RJ (2005) Signalling pathways of the LGR7 and LGR8 receptors determined by reporter genes. Annals of the New York Academy of Sciences 1041: 292-295. (IF = 1.9, Citations = 4)
  16. Bond CP, Parry LJ, Samuel CS, Gehring HM, Lederman FL, Rogers PAW and Summers RJ (2005) Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle. Annals of the New York Academy of Sciences 1041: 136-143. (IF = 1.9, Citations = 0)
  17. Halls ML, Bathgate RAD, Bond CP and Summers RJ (2005) Identification of binding sites with differing affinity and potency for relaxin analogues on LGR7 and LGR8 receptors. Annals of the New York Academy of Sciences 1041: 17-21. (IF = 1.9, Citations = 0)
  18. Tregear GW, Bathgate RAD, Layfield S, Ferraro T, Gundlach A, Ma S, Lin F, Hanson NF, Summers RJ, Rosengren J, Craik DJ and Wade JD (2005) The chemistry and biology of relaxin-3. Annals of the New York Academy of Sciences 1041: 40-46. (IF = 1.9, Citations = 1)
  19. Halls ML, Bathgate RAD and Summers RJ (2005) Signal switching following stimulation of LGR7 receptors by human relaxin 2. Annals of the New York Academy of Sciences 1041: 288-291. (IF = 1.9, Citations = 7)
  20. Bathgate RAD, Hsueh AJ, Ivell R, Sanborn BM, Sherwood OD and Summers RJ (2005) Receptors for relaxin family peptides. Annals of the New York Academy of Sciences 1041: 61-76. (IF = 1.9, Citations = 7)
  21. Samuel CS, Zhao C, Bathgate RAD, Du XJ,Summers RJ, Amento EP, Walker LL, McBurnie M, Zhao L and Tregear GW (2005) The relaxin gene knockout mouse: A model of progressive fibrosis. Annals of the New York Academy of Sciences 1041: 173-181. (IF = 1.9, Citations = 9)
  22. van der Westhuizen ET, Sexton PM, Bathgate RAD and Summers RJ (2005) Responses of GPCR135 to human gene 3 (H3) relaxin in CHO-K1 cells determined by microphysiometry. Annals of the New York Academy of Sciences 1041: 332-337. (IF = 1.9 Citations = 7)
  23. Halls, M.L., Bond, C.P., Sudo, S., Kumagai, J., Ferraro, T., Layfield, S., Bathgate, R.A.D. and Summers, R.J. (2005) Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 & LGR8). Journal of Pharmacology and Experimental Therapeutics 313: 677-687. (IF = 4.1, Citations = 20)
  24. Halls ML, Bathgate RAD and Summers RJ (2006) Relaxin family peptide receptors, RXFP1 and RXFP2, activate cAMP signalling by distinct mechanisms. Molecular Pharmacology 70, 214-26 (IF = 5.1, Citations = 2) Senior author, original concept, MLH PhD student supervision, data analysis, manuscript preparation
  25. Nevzorova J, Evans BA, Bengtsson T and Summers RJ (2006) Multiple signalling pathways involved in β2-adrenoceptor mediated glucose uptake in rat skeletal muscle cells. British Journal of Pharmacology 147: 446-454. (IF = 3.5, Citations = 4) Senior author, original concept, JN PhD student supervision, data analysis, manuscript preparation
  26. Sato, M., Horinouchi, T., Hutchinson, D.S., Evans, B.A. & Summers, R.J. (2007) Ligand-directed signaling at the β3 -adrenoceptor produced by SR59230A relative to receptor agonists Molecular Pharmacology (in press, August 2007) (IF = 5.1, Citations = N/A) Senior author, original concept, MS PhD student supervision, data analysis, manuscript preparation
  27. van der Westhuizen, E.T., Werry, T.D., Sexton, P.M. & Summers, R.J. (2007) The Relaxin Family Peptide Receptor 3 (RXFP3) activates ERK1/2 through a PKC dependent mechanism in CHO-K1 and HEK293 cells stably expressing the receptor. Molecular Pharmacology  71, 1618-29 (IF = 5.1, Citations = 0) Senior author, original concept, EvdW PhD student supervision, data analysis, manuscript preparation
  28. Hutchinson DS, Summers RJ, Gibbs ME. (2007) β2- and β3 -Adrenoceptors activate glucose uptake in chick astrocytes by distinct mechanisms: a mechanism for memory enhancement? J Neurochem (accepted MS JNC-E-2007-0185.R1 18 June 2007). [IF 4.7] Original concept, manuscript preparation
  29. Halls, M.L., Bathgate, R.A. &Summers, R.J. (2007) Comparison of signaling pathways activated by the relaxin family peptide receptors, RXFP1 and RXFP2, revealed using reporter genes.  J Pharmacol exp Ther, 320, 281-290 (IF = 4.1 , Citations = 0) Senior author, original concept, MLH PhD supervision, data analysis, manuscript preparation
  30. Moore, X-L., Tan, S-L., Lo, C-L., Fang, L., Su, Y-D, Gao, X-M., Woodcock, E.A., Summers, R.J., Tregear, G.W., Bathgate, R.A.D. & Du, X-J. (2007). Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes. Endocrinology, 148(4):1582-9 (IF = 5.2, Citations = 0)
  31. Hutchinson, D.S., Summers, R.J. & Gibbs, M.E. (2008) Energy metabolism and memory processing: Role of glucose transport and glycogen in responses to adrenoceptor activation in the chicken Brain Research Bulletin 76, 224–234
  32. Mookerjee, M., Hewitson, T.D., Halls, M.L., Summers, R.J., Mathai, M.L., Bathgate, R.A.D., Tregear, G.W. & Samuel, C.S. (2008) Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway and Smad2  FASEB J in press Nov
  33. Hutchinson DS, Summers RJ, Bengtsson T. (2008) Regulation of AMP-activated protein kinase activity by G-protein coupled receptors: Potential utility in treatment of diabetes and heart disease. Pharmacol Ther 119, 291-310
  34. Summers, RJ (2008) Atypical pharmacologies atβ-adrenoceptors. Brit J Pharmacol 155, 285-287
  35. Sato, M., Hutchinson, D.S., Evans , B.A. & Summers, R.J. (2008) The β3-adrenoceptor agonist L755507 and antagonist L748337 activate different signalling pathways in CHO-K1 cells stably expressing the human β 3 -adrenoceptor.Mol Pharmacol   74, 1417-1428 [IF 4.469]
  36. Davis E, Loiacono R & Summers RJ. (2008) The rush to adrenaline: drugs in sport acting on the β-adrenergic system. Brit J Pharmacol 154, 584-597
  37. Gibbs ME, Bowser DN, Hutchinson DS, Loiacono RE  & Summers RJ (2008) Memory processing in the avian hippocampus involves interactions between β- adrenoceptors, glutamate receptors and metabolism. Neuropsychopharmacology 33, 2831-46 [IF 5.889]
  38. Sato M, Hutchinson DS, Evans BA & Summers RJ. (2007) Functional domains of the mouse β 3 < /sub > -adrenoceptor associated with differential G-protein coupling. Biochem Soc Trans 35, 1035-1037 [IF 2.962]
  39. Gibbs ME, Hutchinson DS & Summers RJ (2008) Role of  β-adrenoceptors in memory consolidation: β3-adrenoceptors act on glucose uptake and β2; -adrenoceptors on glycogenolysis. Neuropsychopharmacology 33(10):2384-97 [IF 5.889]
  40. Gibbs ME, Maksel D, Gibbs Z, Hou X, Summers RJ, Small DH. (2008)Memory loss caused by beta-amyloid protein is rescued by a β3-adrenoceptor agonist. Neurobiology of Aging in press PMID: 18632189


Reviews

  1. Summers RJ, Broxton N, Hutchinson DS and Evans BA (2004) The Janus faces of adrenoceptors: factors controlling the coupling of adrenoceptors to multiple signal transduction pathways. Clinical and Experimental Pharmacology and Physiology 31: 822-827. (IF = 1.6, Citations = 2)
  2. Bathgate, R.A.D., Ivell, R., Sanborn, B.M., Sherwood, O.D. and Summers, R.J. (2005) International Union of Pharmacology (IUPHAR); Recommendations for the nomenclature of receptors for relaxin family peptides. Pharmacological Reviews 58: 7-31. (IF = 21.9, Citations = 17)
  3. Samuel CS, Du XJ, Bathgate RAD and Summers RJ (2006) Relaxing the stiffened heart and arteries: Therapeutic potential of relaxin in cardiovascular disease. Pharmacology and Therapeutics 112, 529-552  (IF = 7.5, Citations = 2) Senior author, manuscript preparation
  4. van der Westhuizen ET, Summers RJ, Halls ML, Bathgate RAD and Sexton PM (2007) Relaxin receptors - new drug targets for multiple disease states. Current Drug Targets 8, 91-104  (IF = 4.1, Citations = 0)
  5. Halls, M.L., van der Westhuizen, E.T., Bathgate, R.A. & Summers, R.J. (2007) Relaxin Family Peptide Receptors – former orphans reunite with their parent ligands to activate multiple signalling pathways. British Journal of Pharmacology   150(6):677-91 (IF = 3.5, Citations = 0) Senior author, MLH and EVDW student supervision, manuscript preparation

Chapter

  1. Gibbs ME and Summers RJ (2004) Cellular mechanisms of memory formation 4. Neural transmitters and memory formation: I. Principal Transmitters Adrenergic Receptors. In “Memories are made of these: from messengers to molecules.” Riedel G  and Platt B (Editors), Published on line: Eureka.com, Landes Biosciences 2003 Kluwer Academic/Plenum Publishers. 
  2. Tregear GW, Bathgate R, Samuel C, Layfield S, Ferraro T, Gundlach A, Burazin T, Ma, S, Lin F, Wilkinson T, Summers RJ, Rosengren J, Craik DJ and Wade JD (2005) New relaxin peptides: Structure and biological function. In “Peptide Science. Proceedings of the 1st Asia-Pacific International Peptide Symposium.” Shimohagishi Y (Editor), The Japanese Peptide Society, Osaka, pp. 1-4.
  3. Tregear GW, Bathgate RA, Layfield S, Lin F, Hanson NF, Summers RJ, Otvos Jr L and Wade JD (2006) Regio-selective disulfide solid phase synthesis and biology of human relaxin-3, a new member of the insulin superfamily. In “Peptides – Biology and Chemistry. Proceedings of the 2004 Chinese Peptide Symposium.” Liu K and Tam JP (Editors), Shanghai Scientific & Technical Publishers, Shanghai, China (in press, accepted 15th March, 2006)

Other contributions

  2. Summers RJ and Bathgate RAD (2005) Relaxin Family Peptide Receptors.  In “The British Journal of Pharmacology Guide to Receptors and Channels, published as British Journal of  Pharmacology.” (in press); and in Nature Reviews Drug Discovery – www.nature.com/reviews/drugdisc
  3. Summers RJ (2004) α1- , α2- and β- adrenoceptors. In “The British Journal of Pharmacology Guide to Receptors and Channels, published as British Journal of  Pharmacology.” 141 (suppl 1): S8-S10; and in Nature Reviews Drug Discovery – www.nature.com/reviews/drugdisc
  4. Bathgate RAD, Ivell R, Sanborn BM, Sherwood OD andSummers RJ (2006) International Union of Pharmacology: website entry for RXFP1 receptors. www.iuphar.org viewable on http://www.iuphar-db.org/GPCR /ReceptorDisplayForward?receptorID=3022
  5. Bathgate RAD, Ivell R, Sanborn BM, Sherwood OD and Summers RJ (2006) International Union of Pharmacology: website entry for RXFP2 receptors. www.iuphar.org viewable on http://www.iuphar-db.org/GPCR /ReceptorDisplayForward?receptorID=3023
  6. Bathgate RAD, Ivell R, Sanborn BM, Sherwood OD andSummers RJ (2006) International Union of Pharmacology: website entry for RXFP3 receptors. www.iuphar.org viewable on http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3024
  7. Bathgate RAD, Ivell R, Sanborn BM, Sherwood OD and Summers RJ (2006) International Union of Pharmacology: website entry for RXFP4 receptors. www.iuphar.org viewable on http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3037
  8. Summers RJ (2005) α1- , α2- and β- adrenoceptors. In “The British Journal of Pharmacology Guide to Receptors and Channels, published as British Journal of  Pharmacology.” (in press); and in Nature Reviews Drug Discovery – www.nature.com/reviews/drugdisc