Ms Elizabeth Guida

Current Position

Research Assistant

Address

Department of Pharmacology
Monash University
Clayton, Victoria, 3800  Australia

Email: elizabeth.guida@monash.edu
Phone:  +61 3 9905 5945
Facsimile:  +61 3 9902 9500

Current project:

Research assistant on CRC funded project “Mouse model for stroke”: to characterize the apoptotic signalling cascade in our model of stroke. Techniques employed: histochemistry, immunohistochemistry using pro- and anti-apoptotic markers, thionin staining, tunel staining, western blotting, Real-time-PCR-arrays and verification of arrays results via Taqman assays.

Journal Publications:

Avlani VA, Langmead CJ, Guida E, Wood MD, Tehan BG, Herdon HJ, Watson JM, Sexton PM, Christopoulos A. Orthosteric and allosteric modes of interaction of novel selective agonists of the M1 muscarinic acetylcholine receptor. Mol Pharm (2010), 78:94-104.

Brait VH, Jackman KA, Walduck AK, Selemidis S, Diep H, Mast AE, Guida E, Broughton BR, Drummond GR, Sobey CG. Mechanisms contributing to cerebral infarct size after stroke: gender, reperfusion, T lymphocytes, and Nox2-derived superoxide. Journal of Cerebral Blood Flow & Metabolism (2010), 1–12.

Johansson PA, Burnstock G, Dziegielewska KM, Guida E, McIntyre P and Saunders NR. Expression and localisation of P2 nucleotide receptor subtypes during development of the lateral ventricular choroid plexus of the rat. European Journal of Neuroscience. (2007), 25:3319-3331.

Dragoni I, Guida E, McIntyre P. The cold and menthol receptor TRPM8 contains a functionally important double cysteine motif. J Biol Chem. (2006) Dec 8;281(49):37353-60.

Lanzafame AA, Guida E, Christopoulos A. Effects of anandamide on the binding and signaling properties of M1 muscarinic acetylcholine receptors. Biochem Pharmacol. (2004 ) Dec 1;68(11):2207-19.

Baird PN, Chu D, Guida E, Vu HT, Guymer R. Association of the M55L and Q192R paraoxonase gene polymorphisms with age-related macular degeneration. Am J Ophthalmol. (2004) Oct;138(4):665-6.

Devlin MG, Smith NJ, Ryan OM, Guida E, Sexton PM, Christopoulos A. Regulation of serotonin 5-HT2C receptors by chronic ligand exposure. Eur J Pharmacol. (2004) Sep 13;498(1-3):59-69.

Baird PN, Guida E, Chu DT, Vu HT, Guymer RH. The epsilon2 and epsilon4 alleles of the apolipoprotein gene are associated with age-related macular degeneration. Invest Ophthalmol Vis Sci. (2004) May;45(5):1311-5.

Vlahos R, Lee KS, Guida E, Fernandes DJ, Wilson JW, Stewart AG. Differential inhibition of thrombin and EGF-stimulated human cultured airway smooth muscle proliferation by glucocorticoids. Pulm. Pharmacol Ther. (2003),16 (3): 171-180.

Guipponi M, Vuagniaux G, Watternhofer M, Shibuya K, Vazquez M, Dougherty L, Scamuffa N, Guida E, Oki M, Rossier C, Hancock M, Buchet K. The transmembrane serine protease (TMPRSS3) mutated in deafness DFNB8/10 activates the epithelial sodium channel (ENaC) in vitro. Hum Mol Genet. (2002), 11 (23): 2829-2836.

Konopka TE, Barker JE, Bamford TB, Guida E, Anderson RL,  Stewart AG. Nitric oxide synthase II gene disruption: implications for tumor growth and vascular endothelial growth factor production. Cancer Res. (2001), 61 (1): 3182-3187.

Ravenhall C, Guida E, Harris T, Koutsoubos V, Stewart AG. The importance of ERK activity in the regulation of cyclin D1 levels and DNA synthesis in human cultured airway smooth muscle. British J Pharm. (2000), 131(1):17-28.

Fernandes D, Guida E, Koutsoubos V, Harris T, Vadiveloo P, Wilson JW, Stewart AG. Glucocorticoids inhibit proliferation, cyclin D1 expression and retinoblastoma protein phosphorylation, but not activity of the extracellular regulated kinases (ERK) in human cultured airway smooth muscle. Am. J. of Respir. Cell Mol. Biol. (1999), 21(1): 77-88.

Stewart AG, Harris T, Fernandes DJ, Schachte LC, Koutsoubos V, Guida E, Ravenhall C, Vadiveloo P, Wilson JW. Beta-2-adrenergic agonists and cAMP arrest in human cultured airway smooth muscle cells in G1 phase of the cell cycle: role of proteasome degradation of cyclin D1. Mol. Pharacol. (1999), 56(5): 1079-1086.

Guida E, Stewart AG. The influence of hypoxia and glucose deprivation on tumour necrosis factor-a and granulocyte-macrophage colony-stimulating factor expression in human cultured monocytes. Int. J. Cellular Physiol. Biochem. (1998), 8: 75-88.

Zhang B, Knight KR, Dowsing B, Guida E, Phan L, Hickey MJ, Morrison WA, Stewart AG. The timing of administration of dexamethasone or the nitric oxide synthase inhibitor, Nitro-L-Arginine Methyl Ester, is critical for effective treatment of ischaemia-reperfusion injury to rat skeletal muscle. Clinical Sciences. (1997), 93: 167-174.