Department of Pharmacology
Clayton, Victoria, 3800 Australia
Phone: +61 3 9905 5954
Facsimile: +61 3 9902 9500
Dr Courtney Judkins completed her PhD in 2004 in the Department of Pharmacology at Monash University, under the supervision of Professors Roger Summers and Geoff Tregear. Courtney’s PhD investigated the pharmacological interactions of different relaxin analogues with the human relaxin receptor expressed endogenously and recombinantly in cell cultures, as well as physiologically in uterine tissue. Courtney joined Dr Grant Drummond’s group in July 2004, where, for the past 6 years (part time), she has been investigating the influence of NADPH oxidase activity on blood vessel reactivity andstructure in cardiovascular disease states such as atherosclerosis and high blood pressure. In 2007, Courtney was awarded a National Heart Foundation Postdoctoral Research Fellowship for these studies.
Courtney has extensive expertise in mouse genetics and breeding and in the generation of novel transgenic strains, and is currently acting in a managerial role within the Vascular Biology and Immunopharmacology Group.
Miller AA, De Silva TM, Judkins CP, Diep H, Drummond GR, Sobey CS. Augmented superoxide production by Nox2-containing NADPH oxidase causes cerebral artery dysfunction during hypercholesterolemia. Stroke, 41(4):784-9, 2010.
Judkins CP, Diep H, Broughton BR, Mast AE, Hooker EU, Miller AA, Selemidis S, Dusting GJ, Sobey CG, Drummong GR. Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/- mice. Am J Physiol Heart Circ Physiol, 298(1):H24-32, 2010.
Judkins CP, Sobey CG, Dang TT, Miller AA, Dusting GJ, Drummond GR. NADPH-Induced Contractions of Mouse Aorta Do Not Involve NADPH Oxidase: A Role for P2X Receptors. J Pharmacol Exp Ther., 317:644-650, 2006.
Halls ML, Bathgate RA, Sudo S, Kumagai J, Bond CP, Summers RJ. Identification of binding sites with differing affinity and potency for relaxin analogues on LGR7 and LGR8 receptors. Ann N.Y. Acad Sci., 1041:17-21, 2005.
Bond CP, Parry LJ, Samuel CS, Gehring HM, Lederman FL, Rogers PAW, Summers RJ. Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle. Ann N.Y. Acad Sci., 1041:1-8, 2005.
Halls ML, Bond CP, Sudo S, Kumagai J, Ferraro T, Layfield S, Bathgate RA, Summers RJ. Multiple Binding Sites Revealed by Interaction of Relaxin Family Peptides with Native and Chimeric Relaxin Family Peptide Receptors 1 and 2 (LGR7 and LGR8). J Pharmacol Exp Ther., 313:677-87, 2005.
Bond CP, Parry LJ, Samuel CS, Gehring HM, Lederman FL, Rogers PAW, Summers RJ. Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle. J. Clin. Endocrinol. Metab., 89: 3477-3485, 2004.
Samuel CS, Zhao C, Bathgate RAD, Bond CP, Burton MD, Parry LJ, Summers RJ, Tang MLK, Amento EP, Tregear GW. Relaxin deficient mice are associated with an age-related progression of pulmonary fibrosis. FASEB J., 17: 121-123, 2003.
Samuel CS, Zhao C, Bond CP, Amento EP, Summers RJ. Relaxin-1 deficient mice develop an age-related progression of renal fibrosis. Kidney Int., 65: 2054-64, 2004.
Tan YY, Dawson NF, Kompa AR, Bond CP, Claasz AA, Wade JD, Tregear GW, Summers RJ. Structural Requirements for the Interaction of Sheep Insulin-like Factor 3 (INSL3) with Relaxin Receptors in Rat Atria. Eur. J. Pharmacol., 457: 153-160, 2002.
Claasz AA, Bond CP, Bathgate RAD, Otvos L, Dawson NF, Summers RJ, Tregear GW, Wade JD. Relaxin-like bioactivity in THP-1 cells of ovine INSL3 analogues. Eur. J. Biochem., 269: 6287-6293, 2002.
Bathgate RAD, Samuel CS, Burazin TCD, Layfield S, Claasz AA, Reytomas IGT, Dawson NF, Zhao C, Bond CP, Summers RJ, Parry LJ, Wade JD, Tregear GW. Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene: Novel members of the relaxin peptide family. J. Biol. Chem., 277: 1148-1157, 2002.
Mathieu MN, Wade JD, Bond CP, Summers RJ, Tregear GW. Synthesis, conformational studies and biological activity of N-mono-biotinylated rat relaxin. J. Peptide Res., 57: 374-382, 2001.