Current Position
NH&MRC Senior Research Fellow
Address
Department of Pharmacology
Monash University
Clayton, Victoria, 3800 Australia
Email: chris.sobey@monash.edu
Phone: +61 3 9905 4189
Facsimile: +61 3 9902 9500
Biography
Associate Professor Chris Sobey obtained his Ph.D. in 1991 in the Department of Physiology at the University of Melbourne, working with Owen Woodman in the area of endothelium and regulation of coronary artery tone. In 1994 he was awarded an NHMRC CJ Martin Fellowship to conduct postdoctoral studies at the University of Iowa with Donald Heistad and Frank Faraci where he gained expertise in the study of cerebral artery function in vivo.
In 1996 he returned to the University of Melbourne where he established the Cerebrovascular Reactivity Laboratory in the Department of Pharmacology. In 2002 he was awarded an NHMRC RD Wright Career Development Award, and in 2005 he was first appointed as an NHMRC Senior Research Fellow. In 2006 he was recruited to the Department of Pharmacology at Monash University where, together with Grant Drummond, he has established the Vascular Biology and Immunopharmacology Group, which comprises more than 20 members.
He is a member of 7 Editorial Boards, has served as a Grant Review Panel member for the NHMRC, and is currently Chief Investigator on 3 NHMRC Project Grants and 3 Grants-in-aid from the National Heart Foundation. He has more than 110 publications, and his research is currently studying vascular diseases involving oxidative stress, inflammation and immunity – especially stroke, atherosclerosis and hypertension.
Chris's work has examined numerous signalling mechanisms regulating the coronary and cerebral circulations, showing that vascular function is substantially altered in a range of diseases including hypertension, subarachnoid haemorrhage, sepsis, ischaemia-reperfusion and hypercholesterolaemia, and that gender differences often exist. His research is now investigating the inflammatory mechanisms occurring in the brain after stroke in order to identify and develop novel approaches to treat clinical stroke patients.
Journal Publications (since 2007)
Rivera J, Walduck AK, Strugnell RA, Sobey CG and Drummond GR. (2012). Chlamydia pneumoniae induces a pro-inflammatory phenotype in murine vascular smooth muscle cells independently of elevating reactive oxygen species. Clinical and Experimental Pharmacology and Physiology (in press).
Coso S, Harrison I, Harrison CB, Vinh A, Sobey CG, Drummond GR, Williams ED and Selemidis S. (2012). NADPH oxidases as regulators of tumor angiogenesis: current and emerging concepts. Antioxidants and Redox Signaling (in press).
Brait VH, Arumugam TV, Drummond GR and Sobey CG. (2012). Importance of T Lymphocytes in brain injury, immunodeficiency, and recovery after cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism (in press).
Bullen ML, Miller AA, Andrews KL, Irvine JC, Ritchie RH, Sobey CG and Kemp-Harper BK. Nitroxyl (HNO) as a vasoprotective signaling molecule. (2012). Antioxidants and Redox Signaling 14:1675-86.
Thundyil J, Pavlovski D, Sobey CG and Arumugam TV. (2012). Adiponectin receptor signalling in the brain. British Journal of Pharmacology 165:313–327.
Lim R and Sobey CG. (2011). Maternal nicotine exposure and fetal programming of vascular oxidative stress in adult offspring. British Journal of Pharmacology 164:1397-1399.
Drummond GR, Selemidis S, Griendling KK and Sobey CG. (2011). Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets. Nature Reviews Drug Discovery 10:453-471.
De Silva TM, Brait VH, Drummond GR, Sobey CG and Miller AA. (2011). Augmented superoxide production by Nox2-containing NADPH oxidase causes cerebral artery dysfunction during hypercholesterolemia. PLoS ONE 6:e28393
Bullen ML, Miller AA, Dharmarajah J, Drummond GR, Sobey CG and Kemp-Harper BK. (2011). Vasorelaxant and anti-aggregatory actions of the nitroxyl donor, isopropylamine NONOate, are maintained in hypercholesterolemia. (2011). American Journal of Physiology (Heart Circulatory Physiology) 301:H1405-H1414.
Arumugam TV, Cheng Y-L, Choi Y-H, Choi Y, Yang S, Yun Y-K, Park J-S, Yang D-K, Thundyil J, Gelderblom M, Tang S-C, Chan SL, Magnus T, Sobey CG and Jo D-G. (2011). Evidence that γ-secretase-mediated Notch signaling induces neuronal cell death via the NFκB-Bim pathway in ischemic stroke. Molecular Pharmacology 80:23-31.
Jackman KA, Brait VH, Wang Y, Maghzal GJ, Ball HJ, Mckenzie G, De Silva TM, Stocker R and Sobey CG. (2011) Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia-reperfusion in mice. Naunyn-Schmiedeberg’s Archives of Pharmacology 383:471-81.
Woodruff TM, Thundyil J, Tang S-C, Sobey CG, Taylor SM, Arumugam TV. (2011). Pathophysiology, treatment, and animal and cellular models of human ischemic stroke. Molecular Neurodegeneration 6:11.
Chrissobolis S, Miller AA, Drummond GR, Kemp-Harper BK and Sobey CG. (2011). Oxidative stress and endothelial dysfunction in cerebrovascular disease. Frontiers in Bioscience 16:1733-1745.
Brait VH, Rivera J, Broughton BRS, Lee S and Sobey, CG. (2011). Chemokine-related gene expression in the brain following ischemic stroke: no role for CXCR2 in outcome. Brain Research 1372:169-179.
Dharmarajah J, Arthur JF, Sobey CG and Drummond GR. (2010) The anti-platelet effects of apocynin in mice are not mediated by inhibition of NADPH oxidase activity. Naunyn Schmiedeberg’s Archives of Pharmacology 382:377-84.
Budzyn K, Sobey CG, Drummond GR. (2010). Reduced cerebrovascular remodeling and functional impairment in spontaneously hypertensive rats following combined treatment with suboptimal doses of telmisartan and ramipril: is less really more? Journal of Hypertension 28:1384-1389.
Rivera R, Sobey CG, Walduck A, Drummond GR. (2010). Nox isoforms in vascular pathophysiology: insights from transgenic and knockout mouse models. Redox Report 15:50-63.
Miller AA, Budzyn K, Sobey CG. (2010). Vascular dysfunction in cerebrovascular disease: mechanisms and therapeutic intervention. Clinical Science 119:1-17.
Brait VH, Jackman KA, Walduck A, Selemidis S, Diep H, Mast AE, Broughton BRS, Drummond GR, Sobey CG. (2010) Mechanisms contributing to cerebral infarct size after stroke – gender, reperfusion, T lymphocytes and Nox2-derived superoxide. Journal of Cerebral Blood Flow and Metabolism 30:1306-1317.
Broughton BRS, Miller AA, Sobey CG. (2010) Endothelium-dependent relaxation by G protein coupled receptor 30 agonists in rat carotid arteries. American Journal of Physiology (Heart Circulatory Physiology) 298:H1055-H1061.
Miller AA, De Silva TM, Judkins CP, Diep H, Drummond GR, Sobey CG. (2010) Augmented superoxide production by Nox2-containing NADPH oxidase causes cerebral artery dysfunction during hypercholesterolemia. Stroke 41:784-789.
Judkins CP, Diep H, Broughton BRS, Mast AE, Hooker EU, Miller AA, Selemidis S, Dusting GJ, Sobey CG, Drummond GR. (2010) Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability and early atherosclerotic plaque formation in ApoE-/- mice. American Journal of Physiology (Heart Circulatory Physiology) 298:H24-H32.
Harrison CB, Drummond GR, Sobey CG, Selemidis S. (2010) Evidence that nitric oxide inhibits vascular inflammation and superoxide production via a p47phox- dependent mechanism in mice. Clinical and Experimental Pharmacology and Physiology 37:429-34.
Broughton BRS, Reutens DC, Sobey CG. (2009) Apoptotic mechanisms following cerebral ischemia. Stroke 40:e331-e339.
Jackman KA, Miller AA, Drummond GR, Sobey CG. (2009) Importance of NOX1 for angiotensin II-induced cerebrovascular superoxide production and cortical infarct volume following ischemic stroke. Brain Research 1286:215-220.
Peshavariya H, Dusting GJ, Jiang F, Halmos LR, Sobey CG, Drummond GR, Selemidis S. (2009) NADPH oxidase isoform selective regulation of endothelial cell proliferation and survival. Naunyn-Schmiedeberg’s Archives of Pharmacology 380:193–204.
Miller AA, Drummond GR, De Silva TM, Mast AE, Hickey H, Williams JP, Broughton BRS, Sobey CG. (2009) NADPH oxidase activity is higher in cerebral versus systemic arteries of four animal species: Role of Nox2. Am J Physiol Heart Circ Physiol 296:H220–H225.
Jackman KA, Miller AA, De Silva TM, Crack PJ, Drummond GR, Sobey CG. (2009) Reduction of cerebral infarct volume by apocynin requires pre-treatment and is absent in Nox2-deficient mice. British Journal of Pharmacology 156:680-688.
De Silva TM, Broughton BRS, Drummond GR, Sobey CG, Miller AA. (2009) Gender influences cerebral vascular responses to angiotensin II through Nox2-derived reactive oxygen species. Stroke 40:1091-1097.
Selemidis S, Sobey CG, Wingler K, Schmidt HHHW, Drummond GR. (2008) NADPH oxidases in the vasculature: molecular features, roles in disease and pharmacological inhibition. Pharmacology and Therapeutics 120:254-291.
Budzyn K, Ravi RM, Miller AA, Sobey CG. (2008) Mechanisms of augmented serotonin-induced vasoconstriction in spontaneously hypertensive rats. British Journal of Pharmacology 155:210-216.
Miller AA, DeSilva TM, Jackman KA, Sobey CG. (2007) Influence of gender and sex hormones on vascular oxidative stress. Clinical and Experimental Pharmacology and Physiology 34:1037–1043.
Budzyn K, Sobey CG. Rho kinases and their therapeutic applications. (2007) Current Opinion in Drug Discovery & Development 10:590-596.
Jackman KA, Woodman OL, Sobey CG. (2007) Isoflavones, equol and cardiovascular disease: pharmacological and therapeutic insights. Current Medicinal Chemistry 14:2824-2830.
Miller AA, Drummond GR, Mast AE, Schmidt HHHW, Sobey CG. (2007) Effect of gender on NADPH oxidase activity, expression and function in the cerebral circulation: role of estrogen. Stroke 38:2142-2149.
Jackman KA, Woodman OL, Chrissobolis S, Sobey CG. (2007) Vasorelaxant and antioxidant activity of the isoflavone metabolite equol in carotid and cerebral arteries. Brain Research 1141:99-107.
