Dr Brad Broughton

Department of Pharmacology Teaching Research PhD and honours programs Staff Profiles Publications Seminars Contact Us

Current Position

Foundation for High Blood Pressure Research Fellow

Address

Department of Pharmacology
Monash University
Clayton, Victoria, 3800  Australia

Email: bradley.broughton@monash.edu
Phone:  +61 3 9905 0915
Facsimile:  +61 3 9902 9500

Biography

Dr Brad Broughton completed his Ph.D. in 2005 in the School of Biological and Chemical Sciences at Deakin University.  Dr Broughton’s Ph.D. research examined nitric oxide control of lower vertebrate blood vessels.  Brad then moved to the University of New Mexico in the United States where he was an American Heart Foundation Postdoctoral Fellow.  During this time, the overall focus of his research was to investigate calcium signalling mechanisms associated with chronic hypoxia induced-pulmonary hypertension. Returning to Australia in 2008, Brad joined the Vascular Biology and Immunopharmacology Group in the Department of Pharmacology at Monash University under the supervision of Associate Professor Chris Sobey. 

Dr Broughton is currently a Foundation for High Blood Pressure Research Fellow.  In addition, Brad is an Editorial Board member for ISRN Stroke and a Chief Investigator on an NHMRC project grant as well as a Grant-in-aid from the National Heart Foundation.   In 2008, Brad was awarded a National Heart Foundation Postdoctoral Research Fellowship and in 2011 was the recipient of a Monash University Early Career Strategic Grant.  

The major emphasis of Brad’s research focuses on the mechanisms that contribute to stroke-induced injury. His current studies involve examining the role of G protein-coupled oestrogen receptor signalling in the brain following stroke and using human amnion stem cells to treat stroke.  Dr Broughton currently supervises 2 Honours students, Chantelle Gardiner-Mann and Alexia Muscat.

Recent Publications (since 2007)

1. VLAHOS R, STAMBAS J, BOZINOVSKI S, BROUGHTON BRS, DRUMMOND GR AND SELEMIDIS S. Inhibition of Nox2 Oxidase Activity Ameliorates Influenza A Virus-Induced Lung Inflammation. PLoS Pathogens. 7(2): e1001271, 2011.
2. Brait VH, RIVERA J, BROUGHTON BRS, LEE S, DRUMMOND GR, SOBEY CG. Chemokine-Related Gene Expression in the Brain Following Ischemic Stroke: No Role for CXCR2 in Outcome. Brain Res. 1372: 169-179, 2010.
3. Brait VH, Jackman KA, Walduck AK, Selemidis S, Diep H, Mast AE, Guida E, Broughton BR, Drummond GR, Sobey CG. Mechanisms contributing to cerebral infarct size after stroke: gender, reperfusion, T lymphocytes, and Nox2-derived superoxide.  J Cereb Blood Flow Metab. 30(7):1306-17, 2010.
4. RESTA TC, BROUGHTON BRS, AND JERNIGAN NL. Reactive Oxygen Species and RhoA Signaling in Vascular Smooth Muscle: Role in Chronic Hypoxia-Induced Pulmonary Hypertension. Adv Exp Med Biol. 661:355-73, 2010.
5. Broughton BRS, mILLER aa and Sobey CG. Endothelium-dependent relaxation by G protein coupled receptor 30 agonists in rat carotid arteries.  Am J Physiol Heart Circ Physiol. 298(3):H1055-61, 2010.
6. Broughton BR, Jernigan NL, Norton CE, Walker BR, Resta TC. Chronic hypoxia augments depolarization-induced Ca2+-sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA. Am J Physiol Lung Cell Mol Physiol. 298(2):L232-42, 2010.
7. Judkins CP, Diep H, Broughton BR, Mast AE, Hooker EU, Miller AA, Selemidis S, Dusting GJ, Sobey CG, Drummond GR. Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability and early atherosclerotic plaque formation in ApoE-/- mice. Am J Physiol Heart Circ Physiol. 298: H24-H32, 2010.
8. DE SILVA TM, BROUGHTON BRS, DRUMMOND GR, SOBEY CG, AND MILLER AA. Gender influences cerebral vascular responses to angiotensin II through Nox2-derived reactive oxygen species. Stroke. 40(4): 1091-1097, 2009.
9. Broughton BRS, Reutens DC and Sobey CG. Apoptotic mechanisms following cerebral ischemia. Stroke. 40(5): e331-e339, 2009.
10. Miller AA, Drummond GR, De Silva TM, Mast AE, Hickey H, Williams JP, Broughton BRS, and Sobey CG. NADPH oxidase activity is higher in cerebral versus systemic arteries of four animal species: Role of Nox2. Am J Physiol Heart Circ Physiol.296: H220-H225, 2009.
11. Broughton BRS, Walker BR, and Resta TC. Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries. Am J Physiol Lung Cell Mol Physiol. 294: L797-L806, 2008.
12. BROUGHTON BRS, DONALD JA. Nitric oxide control of large arteries and veins of the crocodile, Crocodylus porosus. J Exp Biol. 210: 129-137, 2007.