Current Position
NHMRC Career Development Award Fellow
Address
Department of Pharmacology
Monash University
Clayton, Victoria, 3800 Australia
Email: alyson.miller@monash.edu
Phone: +61 3 9905 4674
Facsimile: +61 3 9902 9500
Since 2003, Dr Miller’s research has been primarily focused on understanding the enzymatic sources of reactive oxygen species (ROS) in cerebral arteries and to better understand their roles in regulating cerebral artery function during health, and in disease states such as hypertension, hyperercholesterolemia and stroke. Dr Miller has published 24 articles and 1 book chapter, and is currently a Chief Investigator on 2 NHMRC Project Grants. In 2007, she was awarded a Postdoctoral Fellowship from the Foundation for High Blood Pressure Research and was the recipient of a Monash University Early Career Grant. In 2009, Dr Miller was awarded a Biomedical Career Development Award from the NHMRC. In the last 4 years, Alyson has been awarded 3 international and 1 national young investigator awards for her research, including the Niels Lassen Award (2009) from the International Society for Cerebral Blood Flow and Metabolism. Dr Miller serves as a committee member for 2 international societies andis co-convenor of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Cardiovascular Interest Group. Currently Dr Miller co-supervises 2 Ph.D. (Mr. Michael De Silva and Ms Michelle Bullen) and 2 Honours students (Ms Jacqueline Ku and Ms Kate Maxwell) within the Vascular Biology and Immunopharmacology Group.
Journal Publications
Miller AA, Megson IL, Gray GA. Inducible nitric oxide synthase-derived superoxide contributes to hypereactivity in small mesenteric arteries from a rat model of chronic heart failure. British Journal of Pharmacology, 131: 29 – 36, 2000.
Nandi M, Miller A, Stidwill R, Jacques T, Haworth S, Heales S, Vallance P. Pulmonary hypertension in a GTP-cyclohydrolase 1 deficient mouse. Circulation, 111: 2086-2090, 2005.
Miller AA, Hislop AA, Vallance P, Haworth SG. Deletion of the eNOS gene has a greater impact on the pulmonary circulation of male than female mice. American Journal of Physiology-Lung Cellular and Molecular Physiology, 289: L299-L306, 2005.
Sobey CG, Miller AA. Signalling pathways activated by hydrogen peroxide in vascular smooth muscle. Journal of Hypertension, 23:1961-1962, 2005.
Miller AA, Drummond GR, Sobey CG. Selective inhibition of NADPH oxidase isoforms as a therapeutic strategy in hypertension. Drug Discovery Today-Therapeutic Strategies, 2: 187-192, 2005.
Miller AA, Drummond GR, Schmidt HHHW, Sobey CG. NADPH oxidase activity and function are profoundly greater in cerebral versus systemic arteries. Circulation Research, 97:1055-1062, 2005.
Sobey CG, Miller AA. Radicals spark interest in cerebral vasodilator mechanisms. American Journal of Physiology-Cell Physiology, 290: C950-C951, 2006.
Judkins CP, Sobey CG, Dang TT, Miller AA, Dusting GJ, Drummond GR. Contractions to NADPH in mouse isolated aorta do not involve NADPH oxidase: A role for P2X receptors. Journal of Pharmacology and Experimental Therapeutics, 317: 644-650, 2006.
Paravicini TM, Miller AA, Drummond GR, Sobey CG. Flow-induced cerebral vasodilatation in vivo involves activation of phosphatidylinositol-3 kinase, NADPH-oxidase, and nitric oxide synthase. Journal of Cerebral Blood Flow and Metabolism, 26: 836-845, 2006.
Miller AA, Drummond GR, Sobey CG. Novel isoforms of NADPH-oxidase in cerebrovascular control. Pharmacology & Therapeutics,111: 928-948, 2006.
Miller AA, Drummond GR, Sobey CG. Reactive oxygen species in the cerebral circulation: Are they all bad? Antioxidants and Redox Signalling, 8: 1113-1120, 2006.
Miller AA, Dusting GJ, Roulston CL, Sobey CG. NADPH-oxidase activity is elevated in penumbral and non-ischaemic cerebral arteries following stroke. Brain Research, 1111: 111-116, 2006.
Miller AA, Drummond GR, Mast AE, Schmidt HHHW, Sobey CG. Effect of Gender on NADPH-Oxidase Activity, Expression and Function in the Cerebral Circulation: Role of Estrogen. Stroke, 38: 2142-2149, 2007.
Miller AA, De Silva TM, Jackman KA, Sobey CG. Influence of gender and sex hormones on vascular oxidative stress. Clinical and Experimental Pharmacology and Physiology, 34:1037-1043, 2007.
Budzyn K, Ravi RM, Miller AA, Sobey CG. Mechanisms of augmented serotonin-induced vasoconsriction in spontaneously hypertensive rats. British Journal of Pharmacology, 155: 210-216, 2008.
Miller AA, Drummond GR, De Silva TM, Mast AE, Hickey H, Williams JP, Broughton BRS, Sobey CG. NADPH oxidase activity is higher in cerebral versus systemic arteries of four animal species: Role of Nox2. American Journal of Physiology-Heart and Circulatory Physiology, 296: 210-225, 2009.
De Silva TM, Broughton BRS, Drummond GR, Sobey CG, Miller AA. Gender Influences Cerebral Vascular Responses to Angiotensin II Through Nox2-derived reactive oxygen species. Stroke, 40: 1091-1097, 2009.
Jackman KA, Miller AA, De Silva TM, Crack P, Drummond GR, Sobey CG. Reduction of Cerebral Infarct Volume By Apocynin Requires Pre-treatment and Involves Inhibition of Nox2-Containing NADPH Oxidase. British Journal of Pharmacology, 156(4): 680-688, 2009.
Jackman KA, Miller AA, Drummond GR, Sobey CG. Importance of NOX1 for Angiotensin II-induced Cerebrovascular Superoxide Production and Cortical Infarct Volume following Ischemic Stroke. Brain Research, 1286: 215-220, 2009.
Judkins CP, Diep H, Broughton BRS, Mast AE, Hooker E, Miller AA, Selemidis S, Dusting GJ, Sobey CG, Drummond GR. Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/- mice. American Journal of Physiology-Heart and Circulatory Physiology, 298(1): H24-32, 2010.
Gray GA, Patrizio M, Sherry L, Miller AA, Malaki M, Wallace AF, Leiper JM, Vallance P. Immunolocalisation and activity of DDAH I and II in the heart and modification post-myocardial infarction. Acta Histochem, May 28, 2010. [Epub ahead of print]
Miller AA, De Silva TM, Judkins CP, Diep H, Drummond GR, Sobey CG. Augmented Superoxide Production By Nox2-Containing NADPH Oxidase Causes Cerebral Artery Dysfunction During Hypercholesterolemia. Stroke , 41(4): 784-789, 2010.
Broughton BRS, Miller AA, Sobey CG. Endothelium-dependent relaxation and antioxidant effects by G protein-coupled receptor 30 agonists in rat carotid arteries. American Journal of Physiology-Heart and Circulatory Physiology, 298(3): H1055-1061, 2010.
Miller AA, Klaudia B, Sobey CG. Vascular dysfunction in cerebrovascular disease: mechanisms and therapeutic intervention. Clinical Science, 119(1): 1-17, 2010.
Miller AA, Sobey CG. Vascular Biology and Atherosclerosis of Cerebral Arteries. In: Stroke: Pathophysiology, diagnosis and management, 5E. Editors: J.P. Mohr, D. Choi, J.C. Grotta, B.Weir, P.A. Wolg. Churchill Livingstone, New York (in press, submitted September 1, 2008)
