Dr Tracy S. P. Heng, BSc(Biomed)(Hons), PhD
Immune Regeneration Laboratory
My postdoctoral research in the von Boehmer lab (Dana-Farber Cancer Institute, Boston) was directed at developing novel strategies for generating antigen-specific regulatory T cells in animal disease models. I continued my postdoctoral training in the Mathis/Benoist lab (Harvard Medical School, Boston), establishing standardised conditions for gene expression profiling of immune cell populations by high-throughput microarray technology. Currently, my research in the Boyd lab is focussed on developing strategies to complement thymic and immune regeneration with emerging therapies for suppressing aberrant immune responses in animal models and humans.
Chief Investigator, Australian Research Council Linkage Project Grant LP110201169 (Partner Organisation: Mesoblast Limited) (2011-2014).
Heng TSP, Reiseger JJ, Fletcher AL, Leggatt GR, White OJ, Vlahos K, Frazer IH, Turner SJ, Boyd RL (2012). Impact of sex steroid ablation on viral, tumour and vaccine responses in aged mice. PLoS ONE 7: e42677.
Bezman NA, Kim CC, Sun JC, Min-Oo G, Hendricks DW, Kamimura Y, Best JA, Goldrath AW, Lanier LL; Immunological Genome Project Consortium (2012). Molecular definition of the identity and activation of natural killer cells. Nature Immunology (in press).
Miller JC, Brown BD, Shay T, Gautier EL, Jojic V, Cohain A, Pandey G, Leboeuf M, Elpek KG, Helft J, Hashimoto D, Chow A, Price J, Greter M, Bogunovic M, Bellemare-Pelletier A, Frenette PS, Randolph GJ, Turley SJ, Merad M; Immunological Genome Consortium (2012). Deciphering the transcriptional network of the dendritic cell lineage. Nature Immunology 13:888-899.
Narayan K, Sylvia KE, Malhotra N, Yin CC, Martens G, Vallerskog T, Kornfeld H, Xiong N, Cohen NR, Brenner MB, Berg LJ, Kang J; Immunological Genome Project Consortium (2012). Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes. Nature Immunology 13: 511-518.
Malhotra D, Fletcher AL, Astarita J, Lukacs-Kornek V, Tayalia P, Gonzalez SF, Elpek KG, Chang SK, Knoblich K, Hemler ME, Brenner MB, Carroll MC, Mooney DJ, Turley SJ; Immunological Genome Project Consortium (2012). Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks. Nature Immunology 13: 499-510.
Painter MW, Davis S, Hardy RR, Mathis D, Benoist C; Immunological Genome Project Consortium (2011). Transcriptomes of the B and T lineages compared by multiplatform microarray profiling. The Journal of Immunology 186:3047-57.
Heng TSP, Chidgey AP, Boyd RL (2010). Getting back at nature - understanding thymic development and overcoming its atrophy. Current Opinion in Pharmacology 10: 425-433.
Morison J, Heng T, Chidgey A, Boyd R (2011). The immunogenicity of stem cells and thymus-based strategies to minimise immune rejection. In Dr P Fairchild (ed) Immunological Barriers to Regenerative Medicine, Springer Verlag, UK.