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Publications 2007-2008

Peer reviewed publications listed by laboratory

Immunology - stem cells - tolerance and thymic function - Group Leader: Professor Richard Boyd

Barnard, A., D. Layton, M. Hince, S. Sakkal, C. Bernard, A. Chidgey, and R. Boyd, (2008), Impact of the neuroendocrine system on thymus and bone marrow function: Neuroimmunomodulation, v. 15, p. 7-18.

Barnard, A.L., A.P. Chidgey, C.C. Bernard, and R.L. Boyd, Androgen depletion increases the efficacy of bone marrow transplantation in ameliorating experimental autoimmune encephalomyelitis. Blood First Edition Paper, prepublished online September 29, 2008; DOI 10.1182/blood-2008-05-156042.

Chidgey, A.P. and R.L. Boyd, PREVIEWS: Immune privilege for stem cells: not as simple as it looked. Cell Stem Cell, 2008. 3: 357-8.

Chidgey, A.P., N. Seach, J. Dudakov, M.V. Hammett, and R.L. Boyd, Strategies for reconstituting and boosting T cell-based immunity following haematopoietic stem cell transplantation: pre-clinical and clinical approaches. Semin Immunopathol, 2008. E-Pub.

Hince, M., S. Sakkal, K. Vlahos, J. Dudakov, R. Boyd, and A. Chidgey, REVIEW: The role of sex steroids and gonadectomy in the control of thymic involution. Cell Immunol, 2008. 252: 122-138.

Giudice, A. and A. Trounson, REVIEW: Genetic modification of human embryonic stem cells for derivation of target cells. Cell Stem Cell, 2008. 2: 422-433.

Millar, J., R. Boyd, and J. Sutherland, LETTER TO THE EDITOR: An Update of the Phase III Trial Comparing Whole Pelvic to Prostate Only Radiotherapy and Neoadjuvant to Adjuvant Total Androgen Suppression: Updated Analysis of RTOG 94-13, With Emphasis on Unexpected Hormone/Radiation Interactions: In Regard to Lawton et al. (Int J Radiat Oncol Biol Phys 2007;69:646-655.). Int J Radiat Oncol Biol Phys, 2008. 71: 316.

Chidgey, A.P. (2008) Effects of growth hormone in enhancing thymic regrowth and immune reconstitution. Expert Rev Clinical Immunol 4(4): 433-439

Kelly, R.M., Highfill, S.L., Panoskaltsis-Mortari, A., Taylor, P.A., Boyd, R.L., Hollander, G.A., and Blazar, B.R. (2008) Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution following murine bone marrow transplantation. Blood First Edition, Prepublished online March 11, 2008; DOI 10.1182/blood-2008-01-136531

Layton DS, Bean AG, Dodge N Strom ADG, Sandrin MS, Ierino FL (2008) Modified porcine dendritic cells: Distinct cytokine expression and differential regulation of human anti-pig xenogeneic responses. Xenotransplantation (accepted)

Chidgey, A.P., Layton, D., Trounson, A., Boyd, R.L. (2008) Tolerance strategies for stem-cell-based therapies. Nature 453: 330 – 337

Seach, N., Ueno, T., Fletcher, A.L., Lowen, T., Mattesich, M., Engwerda, C.R., Scott, H.S., Ware, C.F., Chidgey, A.P., Gray, D.H., Boyd, R.L. (2008) The lymphotoxin pathway regulates Aire-independent expression of ectopic genes and chemokines in thymic stromal cels. J.Immunol. 180: 384-92

Kenins, L., Gill, J.W., Boyd, R.L., Hollander, G.A., and Wodnar-Filipowicz, A., (2008) Intra-thymic expression of Flt3 ligand enhances thymic recovery following irradiation, J Exp Med, (in press) doi:10.1084/jem.20072065

Sutherland, JS., Spyroglou, L., Muirhead, J.L., Heng, T.S., Prieto-Hinojosa, A., Prince, H.M., Chidgey, A.P., Schwarer, A.P, Boyd, R.L. (2008) Enhanced immune system regeneration in humans following allogeneic or autologous hemopoietic stem cell transplantation by temporary sex steroid blockade. Clin Cancer Res 15: 1138-49

Gray, D.H., Fletcher, A.L., Hammett, M., Seach, N., Ueno, T., Young, L.F., Barbuto, J., Boyd, R.L, Chidgey, A.P. (2008) Unbiased analysis, enrichment and purification of thymic stromal cells. J Immunol Methods 329: 56-66

Chidgey, A., Dudakov, J, Seach, N., Boyd, R. (2008) Impact of niche aging on thymic regeneration and immune reconstitution. Semin Immunol 19:331-40

Soh, C-L., Lim, J.M.C., Boyd, R.L., Chidgey, A.P. (2008) Epithelial stem cells and the development of the thymus, parathyroid and skin.Regulatory Networks in Stem Cells. Humana/Springer Press (Book chapter) In Press.

Fletcher, A.L., and Boyd, R.L., (2008) Immunology, In Scientifica, - The comprehensive guide to the world of science, Sydney: Millenium. In press.

Dudakov, J.A., and Boyd, R.L., (2008) Stem Cells, In Scientifica, - The comprehensive guide to the world of science, Sydney: Millenium. In press.

Fletcher, A.L., Reiseger, J.J., Vlahos, K., Seach, N.L., Dudakov, J.A., Chidgey, A.P., and Boyd, R.L. (2008) Thymic regeneration in mice and humans following sex steroid ablation. In Fulop, T., Hirokawa, K., Franceschi, C., and Pawelec, G. (Eds) Handbook on Immunosenescence, Springer. In press.

Seach N, Layton D, Lim J, Chidgey A and R. Boyd (2007) Thymic generation and regeneration: a new paradigm for establishing clinical tolerance of stem cell-based therapies. Curr Opin Biotec 18:1-7.

Rossi SW, Chidgey AP, Parnell SM, Jenkinson WE, Scott HS, Boyd RL, Jenkinson EJ, Anderson G.(2007) Redefining epithelial progenitor potential in the developing thymus. Eur J Immunol. 37(9): 2411-8.

Goldberg GL, Alpdogan O, Muriglan SJ, Hammett MV, Milton MK, Eng JM, Hubbard VM, Kochman A, Willis LM, Greenberg AS, Tjoe KH, Sutherland JS, Chidgey A, van den Brink MR, Boyd RL.(2007) Enhanced immune reconstitution by sex steroid ablation following allogeneic hemopoietic stem cell transplantation (2007) J Immunol. 178(11):7473-84.

Gray DH, Tull D, Ueno T, Seach N, Classon BJ, Chidgey A, McConville MJ, Boyd RL. (2007) A unique thymic fibroblast population revealed by the monoclonal antibody MTS-15. J Immunol. 178(8):4956-65.

Chidgey, A., Boyd, R., Hugo, P. (2007) The thymic niche and thymopoiesis. Encylopedia of Life Sciences doi: 10.1002/9780470015902.a0000526.pub2

Layton DS, Strom AD, O'Neil TE, Broadway MM, Stephenson GL, Morris KR Muralitharan M, Sandrin MS, Ierino FL, Bean AG (2007) Development of an anti-porcine CD34 monoclonal antibody that identifies hematopoietic stem cells. Exp Hematol. 35: 171-8.

Wilson, T.J., Truman, D., Giudice, A., and Hertzog, P. (2007). Rapid generation of gene-targeting constructs. Chapter 11 In: PCR Methods Express. Edited by S. Hughes and A. Moody. Scion Publishing Ltd.

Book chapters

Fletcher, A.L., and Boyd, R.L., (2008) Immunology, In Scientifica, - The comprehensive guide to the world of science, Sydney: Millenium, pp.344-345

Dudakov, J.A., and Boyd, R.L., (2008) Stem Cells, In Scientifica, - The comprehensive guide to the world of science, Sydney: Millenium. pp. 286-287

Soh, C., Lim, J.M.C., Boyd, R.L., and Chidgey, A.P., (2008) Epithelial stem cells and the development of the thymus, parathyroid and skin. In, Dr V.K. Rajasekhar and Dr M. Vemuri (Eds) Regulatory Networks in Stem Cells, Humana Press Incorporated. In press.

Giudice, A., Lim, J. and Michalska, M. Derivation, Culture and Genetic Modification of Mouse Embryonic Stem Cells. In: Stem Cells: Basics and Applications./ Editor Deb, K.D. McGraw Hill Publishing House (India).

Neuroimmunology - Group Leader: Professor Claude Bernard

Barnard, A., D. Layton, M. Hince, S. Sakkal, C. Bernard, A. Chidgey, and R. Boyd, Impact of the neuroendocrine system on thymus and bone marrow function. Neuroimmunomodulation, 2008. 15: 7-18.

Chan, J., E.J. Ban, K.H. Chun, S. Wang, J. McQualter, C. Bernard, B.H. Toh, and F. Alderuccio, Methylprednisolone induces reversible clinical and pathological remission and loss of lymphocyte reactivity to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis. Autoimmunity, 2008. 41: 405-13.

Siatskas C and Bernard CCA (2008) Stem cell and gene therapeutic strategies for the treatment of multiple sclerosis. Current Molecular Medicine. (Invited Review).

Azari MF, Ozturk E, Profyris C, Wang S, Small DH, Bernard CC, Petratos S. (2008) LIF-treatment reduces Nogo-A deposits in spinal cord injury modulating Rho GTPase activity and CRMP-2 phosphorylation. Journal of Neurodegeneration and Regeneration

Azari, M., Ozturk, E., Profyris, C., Wang, S., Small, D., Bernard, C.C.A. and Petratos, S. Leukemia Inhibitory Factor Arrests Oligodendrocyte Death and Demyelination in Spinal Cord Injury. Journal of Neurodegeneration and regeneration, 2008; 65: 914-929.

Chan, J., Ban, E.J., Chun, K.H., Wang, S., McQualter, J., Bernard, C.C.A., Toh, B.H. and Alderuccio, F. Autoimmunity. (2008) (In press, accepted May 2008).

Petratos S., Li QX., George AJ., Kerr ML., Unabia SE., Hatzinisiriou I., Maksel D., Aguilar MI., Small DH. (2008) The beta-amyloid protein of Alzheimer's disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism. Brain 131, 90-108

Small, D.H. Petratos, S., Unabia, S. and Maksel, D. (2008) Expression of acetylcholinesterase in Alzheimer's disease brain. Role in neuritic dystrophy and synaptic scaling. In Advances in Alzheimer's disease and Parkinson's disease. Insights, Progress, and Perspectives Spinger US Vol 57 p429-437.

Payne, N., Siatskas, C. and Bernard, C. C. (2008) The promise of stem cells and regenerative therapies for multiple sclerosis. J. Autoimmun. In press.

Otaegui O, Mostafavi S, Bernard CCA, Lopez de Munain A, Mousavi P, Oksenberg J R, Baranzini SE (2007) Oksenberg and Sergio E. Baranzini. J Immunol, 179: 4074-4082

Christopher Siatskas and Claude C.A. Bernard (2007) Emerging treatments for Multiple Sclerosis. Australasian Science. 28: 18-22.

Embryonic Stem Cell Differentiation Laboratory - Group Leaders: Professors Andrew Elefanty and Ed Stanley

Lim SM, Pereira L, Wong MS, Hirst CE, Van Vranken BE, Pick M, Trounson A, Elefanty AG, Stanley EG., Enforced Expression of Mixl1 During Mouse ES Cell Differentiation Suppresses Hematopoietic Mesoderm and Promotes Endoderm Formation. Stem Cells. 2008 Nov 26

Davis, R.P., M. Costa, C. Grandela, A.M. Holland, T. Hatzistavrou, S.J. Micallef, X. Li, A.L. Goulburn, L. Azzola, A.G. Elefanty, and E.G. Stanley, A protocol for removal of antibiotic resistance cassettes from human embryonic stem cells genetically modified by homologous recombination or transgenesis. Nat Protoc, 2008. 3:1550-8.

Davis RP, Ng ES, Costa M, Mossman AK, Sourris K, Elefanty AG and Stanley EG. Targeting a GFP reporter gene to the MIXL1 locus of human embryonic stem cells identifies human primitive streak-like cells and enables isolation of primitive hematopoietic precursors. Blood, 111, 1876-1884, 2008

Ng ES, Davis RP, Hatzistavrou T, Stanley EG and Elefanty AG. Directed differentiation of human embryonic stem cells as spin embryoid bodies and a description of the hematopoietic blast colony forming assay. Curr Protoc Stem Cell Biol, 4:1D.3.1-1D.3.23, 2008

Ng ES, Davis R, Stanley EG and Elefanty AG. A protocol describing the use of a recombinant protein-based, animal product free medium (APEL) for human embryonic stem cell differentiation as spin embryoid bodies. Nature Protocols, 3, 768-776, 2008.

Stanley EG and Elefanty AG. Building better beta cells. Cell Stem Cell , 2, 300-301, 2008.

Costa M, Dottori M, Sourris K, Jamshidi P, Hatzistavrou T, Davis R, Azzola L, Jackson S, Lim SM, Pera M, Elefanty AG and Stanley EG (2007) A method for genetic modification of human embryonic stem cells using electroporation. Nature Protocols, 2, 792-796,

Pick M, Azzola L, Mossman A, Stanley EG and Elefanty AG (2007) Differentiation of human embryonic stem cells in serum free medium reveals distinct roles for BMP4, VEGF, SCF and FGF2 in hematopoiesis. Stem Cells, 25, 2206-2014,

Micallef SJ, Li X, Janes ME, Jackson SA, Sutherland RM, Lew AM, Harrison LC, Elefanty AG and Stanley EG (2007) Endocrine cells develop within pancreatic bud-like structures derived from mouse ES cells differentiated in response to BMP4 and retinoic acid. Stem Cell Research, 1, 25-36,

Costa M, Sourris K, Hatzistavrou T, Elefanty AG and Stanley EG (2007). Expansion of human embryonic stem cells in vitro. Curr Protoc Stem Cell Biol, 1:1C.1.1 - 1C.1.7

Micallef SJ, Li X, Elefanty AG and Stanley EG (2007) Pancreas differentiation of mouse ES cells Curr Protoc Stem Cell Biol, 2:1G.2.1- 1G.2.8

Coultas L, Terzano S, Thomas T, Voss A, Reid K, Stanley EG, Scott CL, Bouillet P, Bartlett P, Ham J, Adams JM, Strasser A (2007) Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis. J Cell Sci. 2007 Jun 15;120 (Pt 12):2044-52

Elefanty AG (2007). Inaugural issue of Stem Cell Research. Stem Cell Res, 1, 1-2,

Smith J, Wardle F, Loose M, Stanley E, and Roger R (2007) Patient. Germ Layer Induction in ESC-Following the Vertebrate Roadmap (Review). Curr Protoc Stem Cell Biol, 1:1D.1.1 - 1D.1.22.

Trounson A and Elefanty A (2007) Stem cells in biology, tissue engineering and medicine: the leading edge keeps moving. Curr Opin Biotechnol, 18, 432-3.

Book Chapters

Goulburn A., Trounson A. Therapeutic Applications of Human Embryonic Stem Cells. In: Cell Therapy. Garcia-Olmo D., Garcia-Verdugo J.M., Alemany J., Gonzalez M.A., Gutierrez-Fuentes J.A. McGraw-Hill. 2008.

Costa, M., K. Sourris, T. Hatzistavrou, A.G. Elefanty, and E.G. Stanley, Expansion of human embryonic stem cells in vitro. Curr Protoc Stem Cell Biol, 2008. Chapter 1(May 2008): p. Unit 1C1.1-1C1.7.

Ng, E.S., R.P. Davis, T. Hatzistavrou, E.G. Stanley, and A.G. Elefanty, Directed differentiation of human embryonic stem cells as spin embryoid bodies and a description of the hematopoietic blast colony forming assay. Curr Protoc Stem Cell Biol, 2008. Chapter 1(Jan 2008): p. Unit 1D 3.1 - 3.23.

Fetal Development, Stem Cells and Differentiation Group - Group Leader: Professor Graham Jenkin

Dickinson, H., D.W. Walker, and M. Castillo-Melendez, Onset of feeding at birth-Perinatal development of the hypothalamic mechanisms that induce appetite and feeding in the newborn. Neurosci Lett, 2008. 436: 1-6.

Ireland, Z., H. Dickinson, R. Snow, and D.W. Walker, Maternal creatine: does it reach the fetus and improve survival after an acute hypoxic episode in the spiny mouse (Acomys cahirinus)? Am J Obstet Gynecol, 2008. 198: 431 e1-e6.

Miller SL, Loose JM, Jenkin GM and Wallace EM (2008) The effects of sildenafil citrate (Viagra) on uterine blood flow and wellbeing in the intrauterine growth restricted fetus. Amer J Obstet & Gynae Oct 7th [Epub ahead of print].

Dickinson H, Walker DW and Castillo-Melendez M (2008) Onset of feeding at birth - Perinatal development of the hypothalamic mechanisms that induce appetite and feeding in the newborn. Neuroscience Letters, (In press)

Rodricks C, Gibbs M, Jenkin G and Miller S (2008) The effect of hypoxia at different embryonic ages on impairment of memory ability in chicks. Int J Dev Neuroscience 26: 113-118.

Dickinson H,. Walker DW, Wintour M and Moritz M (2007). Maternal dexamethasone treatment at mid-gestation reduces nephron number and alters renal gene expression in the fetal spiny mouse. Am J Physiol Reg Comp Int Physiol 292: R453-R461

Dickinson H, Moritz K, Wintour EM, Walker DW, and Kett MM (2007) A comparative study of renal function in the desert-adapted spiny mouse and the laboratory-adapted C57BL/6 mouse: response to dietary salt load. Am J Physiol Renal Physiol, 293: F1093-F1098, 2007

Dickinson D and Wintour EM (2007) Can life before birth affect health ever after? Current Women's Health Reviews 3: 79-88

Dickinson H and Walker DW (2007) Managing a colony of spiny mice (Acomys cahirinus) for perinatal research. Australian and New Zealand Council for the Care of Animals in Research and Teaching (ANZCCART) Newsletter, 20: 4-10

Miller S, Chai M, Loose J, Castillo-Melendez M, Walker DW, Jenkin G & Wallace EM (2007) The effects of maternal betamethasone administration on the intrauterine growth-restricted fetus. Endocrinology. 148: 1288-95.

Daley GQ, Trounson AO… et al (2007) The ISSCR Guidelines for Human Embryonic Stem Cell Research. Science 315: 603-604.

Trounson A (2007) A fluid means of stem cell generation. Nature Biotech 25: 62-63.

Alumni/Honorary

Bowles, E.J., R.T. Tecirlioglu, A.J. French, M.K. Holland, and J.C. St John, Mitochondrial DNA transmission and transcription after somatic cell fusion to one or more cytoplasts. Stem Cells, 2008. 26: 775-82. Impact Factor: 7.531 Ranking: 5/138

Cruz, N.T., K.J. Wilson, M.A. Cooney, R.T. Tecirlioglu, I. Lagutina, C. Galli, M.K. Holland, and A.J. French, Putative imprinted gene expression in uniparental bovine embryo models. Reprod Fertil Dev, 2008. 20: 589-97. Impact Factor: 2.805 Ranking: 19/37

Trounson, A. and R.P. Harvey, COMMENTARY: A critical time for stem cell research in Australia. Cell Stem Cell, 2008. 2: 118-22.

Tveden-Nyborg, P.Y., N.I. Alexopoulos, M.A. Cooney, A.J. French, R.T. Tecirlioglu, M.K. Holland, P.D. Thomsen, and N.T. D'Cruz, Analysis of the expression of putatively imprinted genes in bovine peri-implantation embryos. Theriogenology, 2008. 70:1119-1128

Wood, B.R., T. Chernenko, C. Matthaus, M. Diem, C. Chong, U. Bernhard, C. Jene, A.A. Brandli, D. McNaughton, M.J. Tobin, A. Trounson, and O. Lacham-Kaplan, Shedding New Light on the Molecular Architecture of Oocytes Using a Combination of Synchrotron Fourier Transform-Infrared and Raman Spectroscopic Mapping. Anal Chem, 2008. E-Pub.

Book Chapter

Van Vranken, B.E., H.J. Rippon, A. Samadikuchaksaraei, A.O. Trounson, and A.E. Bishop, The differentiation of distal lung epithelium from embryonic stem cells. Curr Protoc Stem Cell Biol, 2007. Chapter 1 (July 2007): p. Unit 1G 1.1 - 1.22.

Stem Cell Therapies for Reproductive and Genetic Disorders Group - Group Leader: Dr David Cram

Lacham-Kaplan, O. and A. Trounson "Reduced developmental competence of immature, in-vitro matured and postovulatory aged mouse oocytes following IVF and ICSI" in Reproductive Biology and Endocrinology 2008, 6:58 doi:10.1186/1477-7827-6-58. This work was supported by the NIH.

Jones, G.M., D.S. Cram, B. Song, G. Kokkali, K. Pantos, and A.O. Trounson, Novel strategy with potential to identify developmentally competent IVF blastocysts. Hum Reprod, 2008. 23: 1748-1759.

Jones, G.M., D.S. Cram, B. Song, M.C. Magli, L. Gianaroli, O. Lacham-Kaplan, J.K. Findlay, G. Jenkin, and A.O. Trounson, Gene expression profiling of human oocytes following in vivo or in vitro maturation. Hum Reprod, 2008. 23: 1138-1144.

McLachlan, R.I., R.J. Aitken, D. Cram, C. Krausz, and M. O'Bryan, LETTER TO THE EDITOR: Need for Standardization and Confirmation of STS Deletions on the Y Chromosome. Fertil Steril, 2008. 90: 463-464

D Saiti and O Lacham-Kaplan (2008): Density Gradients for the Isolation of Germ Cells from Embryoid Bodies. Reprod Biomed Online, 2008. 16: 730-40.

GM Jones, DS Cram, B Song, MC Magli, L Gianaroli, O Lacham-Kaplan, JK Findlay, G Jenkin and AO Trounson (2008): Gene expression profiling of human oocytes following in-vivo or in-vitro maturation. Hum Reprod (Accepted February 18th 2008)

Jones GM, Cram DS, Song B, Kokkali G, Pantos K, Trounson AO (2008): Novel strategy with potential to identify developmentally competent IVF blastocysts. Hum. Reprod. in press (Epub ahead of print release date Thursday May 8)

TJ Wilson, O. Lacham-Kaplan, J Gould , A Holloway , I Bertoncello , PJ Hertzog, A Trounson. (2007). Comparison of mice born after intracytoplasmic sperm injection with in vitro fertilization and natural mating. Mol Reprod Dev. 74: 512-519.

M West. O Lacham-Kaplan, M Cleary, D Galloway, J Shaw, AO Trounson, MC Paris (2007). In vitro maturation and intracytoplasmic sperm injection of oocytes collected from hormonally stimulated common wombats, Vombatus ursinus. Anim Reprod Sci. 98: 311-321.

Lacham-Kaplan and D Saiti (2007): Oocyte differentiation from embryonic stem cells. In Advances in Fertility Studies and Reproductive Medicine, Eds: Kruger TF, Van Der Spy Z and Kempers RD, Besins Healthcare, Durban, Pp 148-152.

D Saiti and O Lacham-Kaplan (2007): Mouse germ cells development in-vivo and in-vitro. Biomaker Insight 2:241-252.

Munne S, Gianaroli L, Tur-Kaspa I, Magli C, Sandalinas M, Grifo J, Cram DS, Kahraman S, Verlinsky Y, Simpson JL (2007) Sub-standard application of preimplantation genetic screening may interfere with its clinical success. Fertility and Sterility 88: 781-784.

Cram DS, Pope A (2007) Preimplantation genetic diagnosis: current and future perspectives. Journal of Law and Medicine 15: 36-44.

Salvado C and Cram DS (2007). Microarray technology for mutation analysis in low template DNA samples. Methods in Molecular Medicine 132:153-174.

Osborne E, Lynch M, McLachlan R, Trounson AO, Cram DS (2007) Microarray detection of Y chromosome deletions. Reproductive Biomedicine Online 15: 673-680.

Cram DS, Song B, Trounson AO (2007) Genotyping of Rhesus SCNT pluripotent stem cell lines. Nature 450: E12-14.
Jones, G.M., Song, B., Cram, D.S. and Trounson, A.O. (2007) Optimization of a microarray based approach for deriving representative gene expression profiles from human oocytes. Mol. Reprod. Dev. 74: 8-17.

Kokkali G, Traeger-Synodinos J, Vrettou C, Stavrou D, Jones GM, Cram DS, Makrakis E, Trounson AO, Kanavakis E, Pantos K. (2007) Blastocyst biopsy versus cleavage stage biopsy and blastocyst transfer for preimplantation diagnosis of -thalassaemia: a pilot study. Hum Reprod. 22:1443-1449.

Associate Professor Henry Sathananthan - Honorary

Sathananthan, A.H (2007) The derivation of embryonic stem cells for therapy: new technologies. Reproductive BioMedicine Online 14: 635-639.

Sathananthan AH (2007) Embryo morphology in repeated ART failures In: Recurrent Pregnancy Loss. M.Arora, J.C. Konje JC (eds), Jaypee, New Delhi, pp 212-230.

Sathananthan, A.H., Nottola S.A (2007) Digital imaging of stem cells by electron microscopy, In Vermuri, M.C. (ed) Stem Cell Assays: Methods in Molecular Biology Series 407, Humana Press pp 21-42.

Sathananthan, A.H., Trounson, A (2007) In vitro differentiation of human embryonic stem cells, In Sullivan, S .Cowan, C., Eggan, K,(eds) Human Embryonic Stem Cells: A Practical Handbook" Wiley Press pp 149-168

Sathananthan, A.H., Gunasheela, S (2007) Human oocyte and embryo assessment for ART, In Elder, K.,Cohen,J. (eds) Human Preimplantation Embryo Selection 1st ed, Informa, Healthcare pp 1-14

Adult stem cells in renal regeneration and repair - Group Leader: Dr Sharon Ricardo

Ricardo, S.D., H. van Goor, and A.A. Eddy, Macrophage diversity in renal injury and repair. J Clin Invest, 2008. 118: 3522-3530.

Wang L, Weidenfeld R, Verghese L, Ricardo S.D. and Deane JA (2008) Alterations in renal cilium length during transient complete ureteral obstruction in the mouse. J Anat, 2008. 213: 79-85

Verghese L, Weidenfeld R, Bertram JF, Ricardo SD and Deane JA (2008)
Renal cilia display length alterations following tubular injury and are present early in epithelial repair. Nephrol Dialysis and Transplantation 23(3):834-41, 2008.

Ricardo S.D., H van Goor. Eddy A.A. Invited Review: Macrophage diversity in renal injury and repair. J Clin Invest 118(11); 3522-3530, 2008

Ricardo S.D., H van Goor. Eddy A.A (2008) Review: Beyond the Dark Side of the Renal Macrophage. J Clin Invest. Deane JA and Ricardo SD (2007) Polycystic kidney disease and the renal cilium. Nephrology; 12: 559-64.

Li J, Deane JA, Campanale NV, Bertram JF, and Ricardo S.D (2007) Modulation of the contribution of bone marrow-derived cells to renal repair and the development of interstitial fibrosis. Stem Cells 25:697-706,

Rae F, Woods K, Sasmono T, Campanale N, Taylor D, Ovchinnikov D, Grimmond SM, Hume DA, Ricardo S.D, and Little MH (2007) Characterisation and trophic functions of murine embryonic macrophages based upon the use of a CSF-IR-EGFP transgenic reporter. Dev Biol 308:232-246..

Publications 2006

Immunology - stem cells - tolerance and thymic function - Group Leader: Professor Richard Boyd:

Alpdogan O, Hubbard VM, Smith OM, Patel N, Lu SX, Goldberg GL, Gray DH, Feinman J, Kochman AA, Eng JM, Muriglan SJ, Suh D, Boyd RL, van den Brink MR. (2006) Keratinocyte Growth Factor (KGF) Is Required For Post-Natal Thymic Regeneration. Blood, 107(6):2453-60.

Kurobe, H., Liu, C., Ueno, T., Saito, F., Ohigashi, I., Seach, N., Arakaki, R., Hayashi, Y., Kitagawa, T., Lipp, M., Boyd, R.L., and Takahama,Y. (2006) CCR7-dependent cortex to medulla migration of positively selected thymocytes is dispensable for T-cell maturation and thymic export but is essential for establishing central tolerance. Immunity. 24(2):165-77.

Uldrich, A.P., Berzins, S.P., Malin, M.A., Bouillet, P., Strasser, A., Smyth, M.J., Boyd, R.L.* and Godfrey, D.I.* (2006). Antigen challenge inhibits thymic emigration. J. Immunol. 176: 4553-4561
(* equal contribution)

Nijhof JG. Braun KM. Giangreco A. van Pelt C. Kawamoto H. Boyd RL. Willemze R. Mullenders LH. Watt FM. de Gruijl FR. van Ewijk W. (2006) The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells. Development. 133(15):3027-37.

Daniel H.D. Gray, Natalie Seach, Tomoo Ueno, Morag Milton, Adrian Liston, Andrew M. Lew, Christopher C. Goodnow, Richard L. Boyd (2006) Developmental kinetics, turnover and stimulatory capacity of thymic epithelial cells. Blood. 108(12):3777-85.

Chidgey AP and Boyd RL (2006) Stemming the tide of thymic ageing. Nature Immunology. 7(10):1013-6.

Jeremy Millar, Jayne Sutherland, & Richard Boyd (2006) Alternative explanations for T-cell response to in-situ gene therapy for prostate cancer: In reply to Fugita et al (Int. J. Radiation Oncology Biol. Phys., Vol. 65, No. 1, pp. 84-90, 2006). International Journal of Radiation Oncology, Biology, Physics, 66 (5): 1599.

Neuroimmunology - Group Leader: Professor Claude Bernard:

Huntington ND, Tomioka R, Clavarino C, Chow AM, Linares D, Mana P, Rossjohn J, Cachero, TG, Qian F, Kalled SL, Bernard CC, Reid HH. A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responses. Int. Immunol. 2006; 18:1473-1485.

Azari MF, Profyris C, Karnezis T, Bernard CC, Small DH, Cheema SS, Ozturk E, Hatzinisiriou I, Petratos S Leukemia Inhibitory Factor Arrests Oligodendrocyte Death and Demyelination in Spinal Cord Injury. JNEN 2006; 65: 914-929

McQualter JL, Bernard CC. Multiple Sclerosis: A battle between degeneration and repair. J. Neurochem. 2006:100:295-306.

Embryonic Stem Cell Differentiation Laboratory - Group Leaders: Professors Andrew Elefanty and Ed Stanley:

Holland AM, Micallef SJ, Li X, Elefanty AG, Stanley EG (2006) A mouse carrying the green fluorescent protein gene targeted to the Pdx1 locus facilitates the study of pancreas development and function. Genesis. 44(6):304-7.

Hirst CE, Ng ES, Azzola L, Voss AK, Thomas T, Stanley EG and Elefanty AG. Transcriptional profiling of mouse and human ES cells identifies SLAIN1, a novel stem cell gene. Dev Biol, 2006 May 1;293(1):90-103.

Fetal development, stem cells and differentiation
(Incorporating Stem Cells and Differentiation Group of Founding Director Professor Alan Trounson)

Taylor R, Cowin PA, Cunha GR, Pera M, Trounson AO, Pedersen J, Risbridger GP (2006) Formation of human prostate tissue from embryonic stem cells. Nature Methods 3: 179-181.

Lacham-Kaplan O, Chy H, Trounson A (2006) Testicular cell conditioned medium supports differentiation of embryonic stem cells into ovarian structures containing oocytes. Stem Cells 24: 266-273.

Thouas GA, Trounson AO, Jones GM (2006) Developmental effects of sublethal mitochondrial injury in mouse oocytes. Biol. Reprod. 74: 969-977.

Davis T, Song B, Cram DS (2006) Successful preimplantation diagnosis of familial adenatomatous polyposis. Reprod Biomed Online 13: 707-711.

Cram DS, Osborne E, McLachlan RI (2006) Y chromosome microdeletions - implications for assisted conception. Med J Aust 185: 433-434.

Bott EM, Young IR, Jenkin G, McLaren WJ. (2006) Detection of morphological changes of the ovine cervix in response to sex steroids using a fluorescence confocal endomicroscope. American Journal of Obstetrics and Gynaecology 194:105-112.

Supramaniam VG, Jenkin G, Loose J, Wallace EM, Miller SL. (2006) Chronic fetal hypoxia increases activin A concentrations in the late pregnant sheep. British Journal of Obstetrics and Gynaecology 113:102-109.

Yang H, Cox S-L, Jenkin G, Findlay J,Trounson A, Shaw J. (2006) Graft site and gonadotrophin stimulation influences on the number and quality of oocytes from murine ovarian tissue grafts. Reproduction 131:851-859.

Rodricks CL, Miller SL, Jenkin G, Gibbs M. (2006) The role of corticosterone in prehatch-induced memory deficits in chicks. Brain Research 1123:34-41.

Adult stem cells in renal regeneration and repair - Group Leader: Dr Sharon Ricardo

Gillard A, Scarff k, Loveland K, Ricardo SD and Bird PI. Modulation and redistribution of Proteinase Inhibitor 8 (Serpinb8) expression during kidney regeneration. Am J Nephrol 26:34-42, 2006.

Challen GA, Bertoncello I, Deane JA, Ricardo SD, Little MH. The kidneys side population reveals multi-lineage potential and renal functional capacity but also cellular heterogeneity. J Am Soc Nephrol 17(7):1896-912, 2006.

Li J, Deane JA, Campanale NV, Bertram JF, Ricardo SD. Blockade of p38 MAPK and TGF-b1/Smad Signaling Pathways Rescues Bone Marrow-derived Peritubular Capillary Endothelial Cells in Adriamycin-induced Nephrosis. J Am Soc Nephrol 17(10):2799-2811, 2006.

Li J, Campanale NV, Bertram JF, Ricardo SD. p38 MAPK and TGF-b/Smad Signaling Pathways co-ordinate Renal Fibrosis in Adriamycin-induced Nephrosis. Am J Pathol 169(5):1527-1540, 2006.

Li J, Deane JA, Campanale NV, Bertram JF, and Ricardo SD. Modulation of the contribution of bone marrow-derived cells to renal repair and the development of interstitial fibrosis. Stem Cells (published Stem Cell Express Dec 14th), 2006.

Previous Publication Highlights

Goldberg GL, Sutherland JS, Hammet MV, Milton MK, Heng TSP, Chidgey AP, Boyd RL (2005) Sex Steroid Ablation Enhances Lymphoid Recovery Following Autologous Hematopoietic Stem Cell Transplantation. Transplantation. 80(11):1604-13

Heng TS, Goldberg GL, Gray DH, Sutherland JS, Chidgey AP, Boyd RL.(2005) Effects of castration on thymocyte development in two different models of thymic involution. J Immunol. 175(5):2982-93.

Sutherland JS, Goldberg GL, Hammett MV, Uldrich AP, Berzins SP, Heng TS, Blazar BR, Millar JL, Malin MA, Chidgey AP, Boyd RL. (2005) Activation of thymic regeneration in mice and humans following androgen blockade. J Immunol. 175(4):2741-53.

Micallef SJ, Janes ME, Knezevic K, Davis RP, Elefanty AG, Stanley EG. (2005) Retinoic acid induces Pdx1-positive endoderm in differentiating mouse embryonic stem cells. Diabetes. 54(2):301-5.

Ng ES, Davis RP, Azzola L, Stanley EG, Elefanty AG.(2005) Forced aggregation of defined numbers of human embryonic stem cells into embryoid bodies fosters robust, reproducible hematopoietic differentiation. Blood. 106(5):1601-3.

Ng ES, Azzola L, Sourris K, Robb L, Stanley EG, Elefanty AG.(2005) The primitive streak gene Mixl1 is required for efficient haematopoiesis and BMP4-induced ventral mesoderm patterning in differentiating ES cells. Development. 132(5):873-84.

Mossman AK, Sourris K, Ng E, Stanley EG, Elefanty AG.(2005) Mixl1 and oct4 proteins are transiently co-expressed in differentiating mouse and human embryonic stem cells.Stem Cells Dev. 14(6):656-63.

Costa M, Dottori M, Ng E, Hawes SM, Sourris K, Jamshidi P, Pera MF, Elefanty AG, Stanley EG.(2005) The hESC line Envy expresses high levels of GFP in all differentiated progeny. Nat Methods. 2(4):259-60.

Cochrane AL, Kett MM, Samuel CS, Campanale NV, Anderson WP, Hume DA, Little MH, Bertram JF, and Ricardo S.D. Renal structural and functional repair in a mouse model of reversal of ureteral obstruction. J Am Soc Nephrol 16(12):3623-30, 2005.

Cochrane AL, Kett MM, Samuel CS, Campanale NV, Anderson WP, Hume DA, Little MH, Bertram JF, Ricardo SD. (2005) Renal structural and functional repair in a mouse model of reversal of ureteral obstruction J Am Soc Nephrol (12): 3623-30.

Ricardo S.D, and Deane J. Review: Stem Cells in Renal Repair and Remodeling. Nephrology 10(2): 276-282, 2005.

Li J, Deane JA, Campanale NV, Bertram JF, Ricardo S.D. Blockade of p38 MAPK and TGF-b1/Smad Signaling Pathways Rescues Bone Marrow-derived Peritubular Capillary Endothelial Cells in Adriamycin-induced Nephrosis. J Am Soc Nephrol 17(10):2799-2811, 2006. Ricardo S.D, and Deane J. Review: Stem Cells in Renal Repair and Remodeling. Nephrology 10(2): 276-282, 2005.

Stem Cell Reviews

Secrets of the Egg. NATURE Vol 439:9 February 2006
Stem Cell Research... the Road Ahead. Nephrology News & Issues • April 2006